DegronMD

Uniprot ID: Q96T58

Source protein: Msx2-interacting protein

Source gene: SPEN

Class: DEG_ODPH_VHL_1

Location: 2614:2627

E3 ligase: VHL

DEGRON score: 0.5163

ASA_SCORE: 99.6571

COIL: 0.9211

CONS_SCORE: 0.4578

DSS_SCORE: 0.2077

HELIX: 0.0192

FCONS_SCORE: 1.1352

RIG_SCORE: 0.8175

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2624G	TCGA-17-Z062	LUAD	TCGA	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.6457
p.P2612S	TCGA-5L-AAT1	BRCA	TCGA	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.2778
p.P2612S	DO219594	BRCA	ICGC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.2778
p.I2618M	TCGA-A5-A0GP	UCEC	TCGA	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.6507
p.I2618M	DO41109	UCEC	ICGC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.6507
p.R2624Q	TCGA-CG-5720	STAD	TCGA	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.6218
p.R2624Q	DO38623	STAD	ICGC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.6218
p.R2624L	DO228978	LICA	ICGC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.7316
p.V2621F	DO229015	LICA	ICGC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.5957
p.Q2635H	DO229035	LICA	ICGC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.1111
p.S2628R	SIDM00602	Gastric Carcinoma	GDSC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.3056
p.S2628R	ACH-000919	Gastric Cancer	CCLE	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.3056
p.S2628R	IM-95	stomach	COSMIC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.3056
p.A2615V	SIDM01592	Breast Carcinoma	GDSC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.6936
p.D2630V	SIDM01611	Endometrial Carcinoma	GDSC	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.25
p.D2630V	ACH-000996	Endometrial/Uterine Cancer	CCLE	IAPKITSVISRMPV	DEG_ODPH_VHL_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T58	Msx2-interacting protein	DEG_ODPH_VHL_1	2614:2627	IAPKITSVISRMPV	VHL	0.5163	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons