DegronMD

Uniprot ID: Q96T58

Source protein: Msx2-interacting protein

Source gene: SPEN

Class: DEG_SCF_FBW7_1

Location: 2390:2397

E3 ligase: FBXW7

DEGRON score: 0.9429

ASA_SCORE: 101.5125

COIL: 0.9603

CONS_SCORE: 0.3295

DSS_SCORE: 0.8132

HELIX: 0.0173

FCONS_SCORE: 0.9041

RIG_SCORE: 0.5311

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q2386H	TCGA-34-8454	LUSC	TCGA	PHSTPPQS	DEG_SCF_FBW7_1	0.2222
p.Q2386H	DO50094	LUSC	ICGC	PHSTPPQS	DEG_SCF_FBW7_1	0.2222
p.D2401N	TCGA-AR-A1AO	BRCA	TCGA	PHSTPPQS	DEG_SCF_FBW7_1	0.2222
p.D2401N	DO4443	BRCA	ICGC	PHSTPPQS	DEG_SCF_FBW7_1	0.2222
p.S2387N	TCGA-AZ-4315	COAD	TCGA	PHSTPPQS	DEG_SCF_FBW7_1	0.6944
p.S2387N	DO8842	COAD	ICGC	PHSTPPQS	DEG_SCF_FBW7_1	0.6944
p.S2403R	TCGA-EY-A1GQ	UCEC	TCGA	PHSTPPQS	DEG_SCF_FBW7_1	0.1667
p.S2403R	DO43090	UCEC	ICGC	PHSTPPQS	DEG_SCF_FBW7_1	0.1667
p.S2400Y	TCGA-K4-A5RH	BLCA	TCGA	PHSTPPQS	DEG_SCF_FBW7_1	0.25
p.S2400Y	DO219028	BLCA	ICGC	PHSTPPQS	DEG_SCF_FBW7_1	0.25
p.Q2382P	SIDM01062	Breast Carcinoma	GDSC	PHSTPPQS	DEG_SCF_FBW7_1	0.1111
p.Q2382P	ACH-000643	Breast Cancer	CCLE	PHSTPPQS	DEG_SCF_FBW7_1	0.1111
p.Q2382P	HDQ-P1	breast	COSMIC	PHSTPPQS	DEG_SCF_FBW7_1	0.1111
p.Q2396R	ACH-001664	Gastric Cancer	CCLE	PHSTPPQS	DEG_SCF_FBW7_1	0.6218
p.T2399A	ACH-001719	Ovarian Cancer	CCLE	PHSTPPQS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96T58	Msx2-interacting protein	DEG_SCF_FBW7_1	2390:2397	PHSTPPQS	FBXW7	0.9429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons