DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPRY
Uniprot ID:
Q96T58
Source protein:
Msx2-interacting protein
Source gene:
SPEN
Class:
ITCH
Location:
771:774
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.7541
ASA_SCORE:
93.525
COIL:
0.7283
CONS_SCORE:
0.3845
DSS_SCORE:
0.5872
HELIX:
0.2533
FCONS_SCORE:
0.8079
RIG_SCORE:
0.6358
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S765N
TCGA-CN-4727
HNSC
TCGA
PPRY
ITCH
0.6111
p.S765N
DO14258
HNSC
ICGC
PPRY
ITCH
0.6111
p.S765C
TCGA-HU-A4GH
STAD
TCGA
PPRY
ITCH
0.6111
p.S765C
DO47743
STAD
ICGC
PPRY
ITCH
0.6111
p.R781H
TCGA-60-2714
LUSC
TCGA
PPRY
ITCH
0.1389
p.R781H
DO26530
LUSC
ICGC
PPRY
ITCH
0.1389
p.R781L
DO228971
LICA
ICGC
PPRY
ITCH
0.1389
p.R762W
TCGA-55-8506
LUAD
TCGA
PPRY
ITCH
0.0833
p.R762W
DO45390
LUAD
ICGC
PPRY
ITCH
0.0833
p.R784H
TCGA-A6-5661
COAD
TCGA
PPRY
ITCH
0.0556
p.R784H
TCGA-AX-A3G8
UCEC
TCGA
PPRY
ITCH
0.0556
p.R784H
DO8634
COAD
ICGC
PPRY
ITCH
0.0556
p.R784H
DO229050
LICA
ICGC
PPRY
ITCH
0.0556
p.R784H
DO41014
UCEC
ICGC
PPRY
ITCH
0.0556
p.R784H
SIDM00415
B-Cell Non-Hodgkin's Lymphoma
GDSC
PPRY
ITCH
0.0556
Showing 1 to 15 of 15 entries
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Drug responses associated with SPEN mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPRY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O43313
ATM interactor
ITCH
287:290
PPRY
ITCH,NEDD4
0.9841
More...
Q09327
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
ITCH
148:151
PPRY
ITCH,NEDD4
0.9144
More...
Q96SN8
CDK5 regulatory subunit-associated protein 2
ITCH
1239:1242
PPRY
ITCH,NEDD4
0.9754
More...
O00299
Chloride intracellular channel protein 1
ITCH
90:93
PPRY
ITCH,NEDD4
0.8886
More...
O15247
Chloride intracellular channel protein 2
ITCH
96:99
PPRY
ITCH,NEDD4
0.9319
More...
Q96NY7
Chloride intracellular channel protein 6
ITCH
553:556
PPRY
ITCH,NEDD4
0.9782
More...
P30876
DNA-directed RNA polymerase II subunit RPB2
ITCH
81:84
PPRY
ITCH,NEDD4
0.9176
More...
O95793
Double-stranded RNA-binding protein Staufen homolog 1
ITCH
113:116
PPRY
ITCH,NEDD4
0.9455
More...
Q9NQL9
Doublesex- and mab-3-related transcription factor 3
ITCH
365:368
PPRY
ITCH,NEDD4
0.9917
More...
Q8TC29
Enkurin
ITCH
24:27
PPRY
ITCH,NEDD4
0.9988
More...
P54753
Ephrin type-B receptor 3
ITCH
438:441
PPRY
ITCH,NEDD4
0.969
More...
P05198
Eukaryotic translation initiation factor 2 subunit 1
ITCH
232:235
PPRY
ITCH,NEDD4
0.6815
More...
Q5CZC0
Fibrous sheath-interacting protein 2
ITCH
5867:5870
PPRY
ITCH,NEDD4
0.994
More...
Q9NU39
Forkhead box protein D4-like 1
ITCH
266:269
PPRY
ITCH,NEDD4
0.9298
More...
Q14332
Frizzled-2
ITCH
189:192
PPRY
ITCH,NEDD4
0.5291
More...
Q14526
Hypermethylated in cancer 1 protein
ITCH
377:380
PPRY
ITCH,NEDD4
0.9217
More...
Q6VAB6
Kinase suppressor of Ras 2
ITCH
486:489
PPRY
ITCH,NEDD4
0.9326
More...
Q13825
Methylglutaconyl-CoA hydratase, mitochondrial
ITCH
333:336
PPRY
ITCH,NEDD4
0.5278
More...
Q96T58
Msx2-interacting protein
ITCH
771:774
PPRY
ITCH,NEDD4
0.7541
More...
Q9ULH7
Myocardin-related transcription factor B
ITCH
871:874
PPRY
ITCH,NEDD4
0.999
More...
Q9NR12
PDZ and LIM domain protein 7
ITCH
101:104
PPRY
ITCH,NEDD4
0.9771
More...
Q99959
Plakophilin-2
ITCH
191:194
PPRY
ITCH,NEDD4
0.9964
More...
Q9UJV9
Probable ATP-dependent RNA helicase DDX41
ITCH
148:151
PPRY
ITCH,NEDD4
0.9995
More...
A6ND36
Protein FAM83G
ITCH
717:720
PPRY
ITCH,NEDD4
0.7033
More...
Q86TB9
Protein PAT1 homolog 1
ITCH
221:224
PPRY
ITCH,NEDD4
0.9488
More...
Showing 1 to 25 of 36 entries
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