DegronMD - Q09327(MGAT3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T57M	TCGA-17-Z022	LUAD	TCGA	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.7423
p.T57M	TCGA-AA-3811	COAD	TCGA	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.7423
p.T57M	DO7962	COAD	ICGC	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.7423
p.N53K	TCGA-3N-A9WC	SKCM	TCGA	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.2778
p.N53K	DO51234	SKCM	ICGC	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.2778
p.P67L	TCGA-46-6025	LUSC	TCGA	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1667
p.P67L	TCGA-46-6025	LUSC	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.2778
p.P67L	DO26644	LUSC	ICGC	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1667
p.P67L	DO26644	LUSC	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.2778
p.P67S	TCGA-55-7907	LUAD	TCGA	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1667
p.P67S	TCGA-55-7907	LUAD	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.2778
p.P67S	DO25396	LUAD	ICGC	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1667
p.P67S	DO25396	LUAD	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.2778
p.P85S	TCGA-A5-A1OF	UCEC	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.P85S	DO42568	UCEC	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.P85S	SIDM00303	Ovarian Carcinoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.P85S	SIDM00064	Hepatocellular Carcinoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.P85S	SIDM00394	Cervical Carcinoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.P85S	SIDM00556	Neuroblastoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.P85S	SIDM00612	Glioma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.P85S	SIDM00324	Neuroblastoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.P85S	SIDM01570	Ovarian Carcinoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.P85S	SISO	cervix	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.P85S	KINGS-1	central nervous system	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.P85S	TGW	autonomic ganglia	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.P85S	KP-N-YN	autonomic ganglia	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.P85S	HLE	liver	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.P85S	JHOS-4	ovary	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.0833
p.R150W	TCGA-A6-6780	COAD	TCGA	PPRY	ITCH	148:151	Mutation altering degron motif	0.7523
p.R150W	DO10244	COAD	ICGC	PPRY	ITCH	148:151	Mutation altering degron motif	0.7523
p.F50L	TCGA-AC-A23H	BRCA	TCGA	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1944
p.F50L	DO2401	BRCA	ICGC	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1944
p.G65R	TCGA-B5-A1MX	UCEC	TCGA	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.2222
p.G65R	TCGA-B5-A1MX	UCEC	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.2222
p.G65R	DO41999	UCEC	ICGC	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.2222
p.G65R	DO41999	UCEC	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.2222
p.S78L	TCGA-BG-A221	UCEC	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.2778
p.S78L	DO42384	UCEC	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.2778
p.E138K	TCGA-CV-7095	HNSC	TCGA	PPRY	ITCH	148:151	Mutation rewiring degron network	0.0556
p.E138K	DO14252	HNSC	ICGC	PPRY	ITCH	148:151	Mutation rewiring degron network	0.0556
p.Y75C	TCGA-DU-7299	LGG	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation altering degron motif	0.5976
p.Y75C	DO22342	LGG	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation altering degron motif	0.5976
p.P73T	TCGA-E6-A1LX	UCEC	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation altering degron motif	0.7031
p.P73T	DO41020	UCEC	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation altering degron motif	0.7031
p.P62H	TCGA-G3-A25Z	LIHC	TCGA	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.3056
p.P62H	TCGA-G3-A25Z	LIHC	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.1389
p.P62H	DO23078	LIHC	ICGC	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.3056
p.P62H	DO23078	LIHC	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.1389
p.F50S	DO48438	BLCA	ICGC	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1944
p.G65E	DO222642	ESCA	ICGC	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.2222
p.G65E	DO222642	ESCA	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation rewiring degron network	0.2222
p.G142C	DO229018	LICA	ICGC	PPRY	ITCH	148:151	Mutation rewiring degron network	0.1667
p.L152I	DO229037	LICA	ICGC	PPRY	ITCH	148:151	Mutation rewiring degron network	0.3056
p.P55S	DO222632	MELA	ICGC	PVTPQAS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.6752
p.G142N	DO222843	MELA	ICGC	PPRY	ITCH	148:151	Mutation rewiring degron network	0.1667
p.S76F	DO50734	ORCA	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation altering degron motif	0.7982
p.R146W	DO38404	STAD	ICGC	PPRY	ITCH	148:151	Mutation rewiring degron network	0.2778
p.P148S	DO229253	THCA	ICGC	PPRY	ITCH	148:151	Mutation altering degron motif	0.6752
p.P73L	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation altering degron motif	0.7582
p.P73L	ACH-000843	Lung Cancer	CCLE	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation altering degron motif	0.7582
p.P73L	HARA	lung	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation altering degron motif	0.7582
p.T72I	SIDM01161	Other Sarcomas	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation altering degron motif	0.7078
p.T72I	ACH-001274	Sarcoma	CCLE	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation altering degron motif	0.7078
p.T72I	SW982	soft tissue	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation altering degron motif	0.7078
p.R71H	SIDM00178	Melanoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation altering degron motif	0.7133
p.R71H	SIDM00826	Colorectal Carcinoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation altering degron motif	0.7133
p.R71H	SIDM00823	Colorectal Carcinoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	69:76	Mutation altering degron motif	0.7133
p.N141S	ACH-000766	Lung Cancer	CCLE	PPRY	ITCH	148:151	Mutation rewiring degron network	0.1389

Kaplan plot for MGAT3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MGAT3

UniProt ID: Q09327

Entrez ID: 4248

Protein name: Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC 2.4.1.144) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III) (GNT-III) (GlcNAc-T III) (N-acetylglucosaminyltransferase III)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MGAT3 in