DegronMD

Uniprot ID: Q09327

Source protein: Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

Source gene: MGAT3

Class: DEG_SCF_FBW7_1

Location: 55:61

E3 ligase: FBXW7

DEGRON score: 0.8836

ASA_SCORE: 81.0857

COIL: 0.9539

CONS_SCORE: 0.3529

DSS_SCORE: 0.459

HELIX: 0.0149

FCONS_SCORE: 1.0203

RIG_SCORE: 0.6571

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T57M	TCGA-17-Z022	LUAD	TCGA	PVTPQAS	DEG_SCF_FBW7_1	0.7423
p.T57M	TCGA-AA-3811	COAD	TCGA	PVTPQAS	DEG_SCF_FBW7_1	0.7423
p.T57M	DO7962	COAD	ICGC	PVTPQAS	DEG_SCF_FBW7_1	0.7423
p.N53K	TCGA-3N-A9WC	SKCM	TCGA	PVTPQAS	DEG_SCF_FBW7_1	0.2778
p.N53K	DO51234	SKCM	ICGC	PVTPQAS	DEG_SCF_FBW7_1	0.2778
p.P67L	TCGA-46-6025	LUSC	TCGA	PVTPQAS	DEG_SCF_FBW7_1	0.1667
p.P67L	DO26644	LUSC	ICGC	PVTPQAS	DEG_SCF_FBW7_1	0.1667
p.P67S	TCGA-55-7907	LUAD	TCGA	PVTPQAS	DEG_SCF_FBW7_1	0.1667
p.P67S	DO25396	LUAD	ICGC	PVTPQAS	DEG_SCF_FBW7_1	0.1667
p.F50L	TCGA-AC-A23H	BRCA	TCGA	PVTPQAS	DEG_SCF_FBW7_1	0.1944
p.F50L	DO2401	BRCA	ICGC	PVTPQAS	DEG_SCF_FBW7_1	0.1944
p.G65R	TCGA-B5-A1MX	UCEC	TCGA	PVTPQAS	DEG_SCF_FBW7_1	0.2222
p.G65R	DO41999	UCEC	ICGC	PVTPQAS	DEG_SCF_FBW7_1	0.2222
p.P62H	TCGA-G3-A25Z	LIHC	TCGA	PVTPQAS	DEG_SCF_FBW7_1	0.3056
p.P62H	DO23078	LIHC	ICGC	PVTPQAS	DEG_SCF_FBW7_1	0.3056
p.F50S	DO48438	BLCA	ICGC	PVTPQAS	DEG_SCF_FBW7_1	0.1944
p.G65E	DO222642	ESCA	ICGC	PVTPQAS	DEG_SCF_FBW7_1	0.2222
p.P55S	DO222632	MELA	ICGC	PVTPQAS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09327	Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	DEG_SCF_FBW7_1	55:61	PVTPQAS	FBXW7	0.8836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons