DegronMD

Uniprot ID: Q09327

Source protein: Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

Source gene: MGAT3

Class: DEG_SCF_FBW7_1

Location: 69:76

E3 ligase: FBXW7

DEGRON score: 0.9468

ASA_SCORE: 75.25

COIL: 0.8373

CONS_SCORE: 0.3453

DSS_SCORE: 0.5516

HELIX: 0.109

FCONS_SCORE: 0.9835

RIG_SCORE: 0.6929

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P67L	TCGA-46-6025	LUSC	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	0.2778
p.P67L	DO26644	LUSC	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	0.2778
p.P67S	TCGA-55-7907	LUAD	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	0.2778
p.P67S	DO25396	LUAD	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	0.2778
p.P85S	TCGA-A5-A1OF	UCEC	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.P85S	DO42568	UCEC	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.P85S	SIDM00303	Ovarian Carcinoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.P85S	SIDM00064	Hepatocellular Carcinoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.P85S	SIDM00394	Cervical Carcinoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.P85S	SIDM00556	Neuroblastoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.P85S	SIDM00612	Glioma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.P85S	SIDM00324	Neuroblastoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.P85S	SIDM01570	Ovarian Carcinoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.P85S	SISO	cervix	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.P85S	KINGS-1	central_nervous_system	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.P85S	TGW	autonomic_ganglia	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.P85S	KP-N-YN	autonomic_ganglia	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.P85S	HLE	liver	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.P85S	JHOS-4	ovary	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	0.0833
p.G65R	TCGA-B5-A1MX	UCEC	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	0.2222
p.G65R	DO41999	UCEC	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	0.2222
p.S78L	TCGA-BG-A221	UCEC	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	0.2778
p.S78L	DO42384	UCEC	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	0.2778
p.Y75C	TCGA-DU-7299	LGG	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	0.5976
p.Y75C	DO22342	LGG	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	0.5976
p.P73T	TCGA-E6-A1LX	UCEC	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	0.7031
p.P73T	DO41020	UCEC	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	0.7031
p.P62H	TCGA-G3-A25Z	LIHC	TCGA	LLRTPLYS	DEG_SCF_FBW7_1	0.1389
p.P62H	DO23078	LIHC	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	0.1389
p.G65E	DO222642	ESCA	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	0.2222
p.S76F	DO50734	ORCA	ICGC	LLRTPLYS	DEG_SCF_FBW7_1	0.7982
p.P73L	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	0.7582
p.P73L	ACH-000843	Lung Cancer	CCLE	LLRTPLYS	DEG_SCF_FBW7_1	0.7582
p.P73L	HARA	lung	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	0.7582
p.T72I	SIDM01161	Other Sarcomas	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	0.7078
p.T72I	ACH-001274	Sarcoma	CCLE	LLRTPLYS	DEG_SCF_FBW7_1	0.7078
p.T72I	SW982	soft_tissue	COSMIC	LLRTPLYS	DEG_SCF_FBW7_1	0.7078
p.R71H	SIDM00178	Melanoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	0.7133
p.R71H	SIDM00826	Colorectal Carcinoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	0.7133
p.R71H	SIDM00823	Colorectal Carcinoma	GDSC	LLRTPLYS	DEG_SCF_FBW7_1	0.7133

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLRTPLYS

Degron related mutations and impact score

Drug responses associated with MGAT3 mutations

All proteins holding degron of LLRTPLYS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q09327	Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	DEG_SCF_FBW7_1	69:76	LLRTPLYS	FBXW7	0.9468	More...