DegronMD - P05198(EIF2S1)

EIF2S1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T239M	TCGA-AX-A06F	UCEC	TCGA	VMTTT	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.7423
p.T239M	TCGA-AX-A2HC	UCEC	TCGA	VMTTT	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.7423
p.T239M	DO41752	UCEC	ICGC	VMTTT	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.7423
p.T239M	DO41572	UCEC	ICGC	VMTTT	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.7423
p.R234L	TCGA-CR-7395	HNSC	TCGA	PPRY	ITCH	232:235	Mutation altering degron motif	0.7316
p.R234L	DO14274	HNSC	ICGC	PPRY	ITCH	232:235	Mutation altering degron motif	0.7316
p.P232L	TCGA-EO-A22U	UCEC	TCGA	PPRY	ITCH	232:235	Mutation altering degron motif	0.7582
p.P232L	DO43755	UCEC	ICGC	PPRY	ITCH	232:235	Mutation altering degron motif	0.7582
p.M237I	TCGA-F5-6814	READ	TCGA	VMTTT	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.6507
p.M237I	TCGA-K4-A54R	BLCA	TCGA	VMTTT	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.6507
p.M237I	DO48611	BLCA	ICGC	VMTTT	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.6507
p.M237I	DO36556	READ	ICGC	VMTTT	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.6507
p.P233L	TCGA-W3-A825	SKCM	TCGA	PPRY	ITCH	232:235	Mutation altering degron motif	0.7582
p.P233L	DO51272	SKCM	ICGC	PPRY	ITCH	232:235	Mutation altering degron motif	0.7582
p.N222T	SIDM00845	Burkitt's Lymphoma	GDSC	PPRY	ITCH	232:235	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc