DegronMD

Uniprot ID: P05198

Source protein: Eukaryotic translation initiation factor 2 subunit 1

Source gene: EIF2S1

Class: DEG_SPOP_SBC_1

Location: 236:240

E3 ligase: SPOP

DEGRON score: 0.7932

ASA_SCORE: 27.14

COIL: 0.0406

CONS_SCORE: 0.5462

DSS_SCORE: 0.2868

HELIX: 0.004

FCONS_SCORE: 0.8741

RIG_SCORE: 0.8401

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T239M	TCGA-AX-A06F	UCEC	TCGA	VMTTT	DEG_SPOP_SBC_1	0.7423
p.T239M	TCGA-AX-A2HC	UCEC	TCGA	VMTTT	DEG_SPOP_SBC_1	0.7423
p.T239M	DO41752	UCEC	ICGC	VMTTT	DEG_SPOP_SBC_1	0.7423
p.T239M	DO41572	UCEC	ICGC	VMTTT	DEG_SPOP_SBC_1	0.7423
p.M237I	TCGA-F5-6814	READ	TCGA	VMTTT	DEG_SPOP_SBC_1	0.6507
p.M237I	TCGA-K4-A54R	BLCA	TCGA	VMTTT	DEG_SPOP_SBC_1	0.6507
p.M237I	DO48611	BLCA	ICGC	VMTTT	DEG_SPOP_SBC_1	0.6507
p.M237I	DO36556	READ	ICGC	VMTTT	DEG_SPOP_SBC_1	0.6507

Showing 1 to 8 of 8 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05198	Eukaryotic translation initiation factor 2 subunit 1	DEG_SPOP_SBC_1	236:240	VMTTT	SPOP	0.7932	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons