DegronMD - Q8WUF5(PPP1R13L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G62V	TCGA-50-5049	LUAD	TCGA	PPRY	ITCH	67:70	Mutation rewiring degron network	0.1944
p.G62V	DO23705	LUAD	ICGC	PPRY	ITCH	67:70	Mutation rewiring degron network	0.1944
p.S74L	TCGA-BR-4370	STAD	TCGA	PPRY	ITCH	67:70	Mutation blocking phosphorylation signal	0.6667
p.S74L	DO38499	STAD	ICGC	PPRY	ITCH	67:70	Mutation blocking phosphorylation signal	0.6667
p.P464L	TCGA-D1-A16R	UCEC	TCGA	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.1944
p.P464L	TCGA-EA-A439	CESC	TCGA	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.1944
p.P464L	DO222951	BTCA	ICGC	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.1944
p.P464L	DO44297	CESC	ICGC	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.1944
p.P464L	DO41831	UCEC	ICGC	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.1944
p.E463Q	TCGA-DQ-5625	HNSC	TCGA	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.1667
p.E463Q	DO15414	HNSC	ICGC	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.1667
p.P64L	TCGA-EE-A2M5	SKCM	TCGA	PPRY	ITCH	67:70	Mutation rewiring degron network	0.25
p.P64L	DO222423	MELA	ICGC	PPRY	ITCH	67:70	Mutation rewiring degron network	0.25
p.P64L	DO37425	SKCM	ICGC	PPRY	ITCH	67:70	Mutation rewiring degron network	0.25
p.G62R	TCGA-EO-A3AZ	UCEC	TCGA	PPRY	ITCH	67:70	Mutation rewiring degron network	0.1944
p.G62R	DO227987	COCA	ICGC	PPRY	ITCH	67:70	Mutation rewiring degron network	0.1944
p.G62R	DO50078	UCEC	ICGC	PPRY	ITCH	67:70	Mutation rewiring degron network	0.1944
p.P462S	TCGA-EY-A1GU	UCEC	TCGA	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.1389
p.P462S	DO41518	UCEC	ICGC	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.1389
p.P59L	TCGA-VQ-A8PT	STAD	TCGA	PPRY	ITCH	67:70	Mutation rewiring degron network	0.1111
p.P59L	DO51776	STAD	ICGC	PPRY	ITCH	67:70	Mutation rewiring degron network	0.1111
p.E467V	DO228278	LICA	ICGC	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.2778
p.F79L	DO229008	LICA	ICGC	PPRY	ITCH	67:70	Mutation rewiring degron network	0.0833
p.P472T	DO47140	RECA	ICGC	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation altering degron motif	0.7031
p.E459K	DO229456	SKCA	ICGC	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.0556
p.R66M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PPRY	ITCH	67:70	Mutation rewiring degron network	0.3056
p.R66M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPRY	ITCH	67:70	Mutation rewiring degron network	0.3056
p.V484A	SIDM00683	Prostate Carcinoma	GDSC	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.0833
p.V484A	ACH-000977	lymph node	CCLE	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.0833
p.V484A	LNCaP-Clone-FGC	prostate	COSMIC	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.0833
p.P67L	SIDM00172	Head and Neck Carcinoma	GDSC	PPRY	ITCH	67:70	Mutation altering degron motif	0.7582
p.E481V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.1667
p.E481V	ACH-000951	Lung Cancer	CCLE	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.1667
p.E481V	NCI-H2342	lung	COSMIC	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.1667
p.P76L	ACH-000661	Skin Cancer	CCLE	PPRY	ITCH	67:70	Mutation rewiring degron network	0.1667
p.P483L	ACH-000851	Lung Cancer	CCLE	LLTPVLE	DEG_SCF_FBW7_2	469:475	Mutation rewiring degron network	0.1111

Kaplan plot for PPP1R13L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP1R13L

UniProt ID: Q8WUF5

Entrez ID: 10848

Protein name: RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP1R13L in