DegronMD

Uniprot ID: Q8WUF5

Source protein: RelA-associated inhibitor

Source gene: PPP1R13L

Class: DEG_SCF_FBW7_2

Location: 469:475

E3 ligase: FBXW7

DEGRON score: 0.9662

ASA_SCORE: 79.6571

COIL: 0.8519

CONS_SCORE: 0.5343

DSS_SCORE: 0.6993

HELIX: 0.1011

FCONS_SCORE: 1.0264

RIG_SCORE: 0.7344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P464L	TCGA-D1-A16R	UCEC	TCGA	LLTPVLE	DEG_SCF_FBW7_2	0.1944
p.P464L	TCGA-EA-A439	CESC	TCGA	LLTPVLE	DEG_SCF_FBW7_2	0.1944
p.P464L	DO222951	BTCA	ICGC	LLTPVLE	DEG_SCF_FBW7_2	0.1944
p.P464L	DO44297	CESC	ICGC	LLTPVLE	DEG_SCF_FBW7_2	0.1944
p.P464L	DO41831	UCEC	ICGC	LLTPVLE	DEG_SCF_FBW7_2	0.1944
p.E463Q	TCGA-DQ-5625	HNSC	TCGA	LLTPVLE	DEG_SCF_FBW7_2	0.1667
p.E463Q	DO15414	HNSC	ICGC	LLTPVLE	DEG_SCF_FBW7_2	0.1667
p.P462S	TCGA-EY-A1GU	UCEC	TCGA	LLTPVLE	DEG_SCF_FBW7_2	0.1389
p.P462S	DO41518	UCEC	ICGC	LLTPVLE	DEG_SCF_FBW7_2	0.1389
p.E467V	DO228278	LICA	ICGC	LLTPVLE	DEG_SCF_FBW7_2	0.2778
p.P472T	DO47140	RECA	ICGC	LLTPVLE	DEG_SCF_FBW7_2	0.7031
p.E459K	DO229456	SKCA	ICGC	LLTPVLE	DEG_SCF_FBW7_2	0.0556
p.V484A	SIDM00683	Prostate Carcinoma	GDSC	LLTPVLE	DEG_SCF_FBW7_2	0.0833
p.V484A	ACH-000977	lymph_node	CCLE	LLTPVLE	DEG_SCF_FBW7_2	0.0833
p.V484A	LNCaP-Clone-FGC	prostate	COSMIC	LLTPVLE	DEG_SCF_FBW7_2	0.0833
p.E481V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LLTPVLE	DEG_SCF_FBW7_2	0.1667
p.E481V	ACH-000951	Lung Cancer	CCLE	LLTPVLE	DEG_SCF_FBW7_2	0.1667
p.E481V	NCI-H2342	lung	COSMIC	LLTPVLE	DEG_SCF_FBW7_2	0.1667
p.P483L	ACH-000851	Lung Cancer	CCLE	LLTPVLE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUF5	RelA-associated inhibitor	DEG_SCF_FBW7_2	469:475	LLTPVLE	FBXW7	0.9662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons