DegronMD - Q9NR12(PDLIM7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P199R	TCGA-23-2649	OV	TCGA	PASST	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.2778
p.R258L	TCGA-55-8302	LUAD	TCGA	PTPLQS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.3056
p.R245W	TCGA-AX-A2HD	UCEC	TCGA	PTPLQS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.1389
p.S95P	TCGA-CK-5913	COAD	TCGA	DPPRYTFAP	CBL_PTK	100:108	Mutation blocking phosphorylation signal	0.6389
p.S95P	TCGA-CK-5913	COAD	TCGA	PPRY	ITCH	101:104	Mutation blocking phosphorylation signal	0.6111
p.S95P	DO8826	COAD	ICGC	DPPRYTFAP	CBL_PTK	100:108	Mutation blocking phosphorylation signal	0.6389
p.S95P	DO8826	COAD	ICGC	PPRY	ITCH	101:104	Mutation blocking phosphorylation signal	0.6111
p.Y104N	TCGA-DM-A1HB	COAD	TCGA	DPPRYTFAP	CBL_PTK	100:108	Mutation altering degron motif	0.817
p.Y104N	TCGA-DM-A1HB	COAD	TCGA	PPRY	ITCH	101:104	Mutation altering degron motif	0.817
p.S109R	TCGA-ZN-A9VW	MESO	TCGA	DPPRYTFAP	CBL_PTK	100:108	Mutation rewiring degron network	0.3056
p.S109R	TCGA-ZN-A9VW	MESO	TCGA	PPRY	ITCH	101:104	Mutation rewiring degron network	0.1944
p.E208K	DO225334	BRCA	ICGC	PASST	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.25
p.R205P	DO50034	BRCA	ICGC	PASST	DEG_SPOP_SBC_1	201:205	Mutation altering degron motif	0.7512
p.V209I	DO2002	BRCA	ICGC	PASST	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.2222
p.Q92H	DO234150	ESAD	ICGC	DPPRYTFAP	CBL_PTK	100:108	Mutation rewiring degron network	0.1111
p.Q92H	DO234150	ESAD	ICGC	PPRY	ITCH	101:104	Mutation rewiring degron network	0.0833
p.P91L	DO233041	GACA	ICGC	DPPRYTFAP	CBL_PTK	100:108	Mutation rewiring degron network	0.0833
p.P91L	DO233041	GACA	ICGC	PPRY	ITCH	101:104	Mutation rewiring degron network	0.0556
p.P91L	ACH-000565	Colon/Colorectal Cancer	CCLE	DPPRYTFAP	CBL_PTK	100:108	Mutation rewiring degron network	0.0833
p.P91L	ACH-000565	Colon/Colorectal Cancer	CCLE	PPRY	ITCH	101:104	Mutation rewiring degron network	0.0556
p.Q212R	DO233179	GACA	ICGC	PASST	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1389
p.A202T	DO233273	GACA	ICGC	PASST	DEG_SPOP_SBC_1	201:205	Mutation altering degron motif	0.6028
p.H246R	DO233672	GACA	ICGC	PTPLQS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.1667
p.Q196K	DO14284	HNSC	ICGC	PASST	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1944
p.P207T	DO229032	LICA	ICGC	PASST	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.2778
p.L263M	DO229035	LICA	ICGC	PTPLQS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.1667
p.R246W	DO27120	LUSC	ICGC	PTPLQS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.1667
p.R246W	DO51524	PACA	ICGC	PTPLQS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.1667
p.P207L	DO220899	MELA	ICGC	PASST	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.2778
p.P192L	DO222595	MELA	ICGC	PASST	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.0833
p.A98T	DO232224	PBCA	ICGC	DPPRYTFAP	CBL_PTK	100:108	Mutation rewiring degron network	0.2778
p.A98T	DO232224	PBCA	ICGC	PPRY	ITCH	101:104	Mutation rewiring degron network	0.25
p.S244G	DO50127	STAD	ICGC	PTPLQS	DEG_SCF_FBW7_1	252:257	Mutation blocking phosphorylation signal	0.5556
p.A99T	SIDM02039	Colorectal Carcinoma	GDSC	DPPRYTFAP	CBL_PTK	100:108	Mutation rewiring degron network	0.3056
p.A99T	SIDM02039	Colorectal Carcinoma	GDSC	PPRY	ITCH	101:104	Mutation rewiring degron network	0.2778
p.P213L	SIDM01060	Melanoma	GDSC	PASST	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1111
p.P213L	ACH-000882	Skin Cancer	CCLE	PASST	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1111
p.A215T	SIDM01447	Glioblastoma	GDSC	PASST	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.0556
p.S204P	ACH-000364	Primary	CCLE	PASST	DEG_SPOP_SBC_1	201:205	Mutation altering degron motif	0.6752
p.R195S	ACH-000804	Neuroblastoma	CCLE	PASST	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1667
p.P101L	ACH-000836	Head and Neck Cancer	CCLE	DPPRYTFAP	CBL_PTK	100:108	Mutation altering degron motif	0.6471
p.P101L	ACH-000836	Head and Neck Cancer	CCLE	PPRY	ITCH	101:104	Mutation altering degron motif	0.7582
p.V193M	ACH-000972	Endometrial/Uterine Cancer	CCLE	PASST	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1111
p.P118S	ACH-000988	Endometrial/Uterine Cancer	CCLE	DPPRYTFAP	CBL_PTK	100:108	Mutation rewiring degron network	0.0556
p.P213S	ACH-001443	Thyroid Cancer	CCLE	PASST	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1111
p.V242G	ACH-002680	Brain Cancer	CCLE	PTPLQS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.0556
p.G252W	GP5d	large intestine	COSMIC	PTPLQS	DEG_SCF_FBW7_1	252:257	Mutation altering degron motif	0.7825
p.P101S	RKO	large intestine	COSMIC	DPPRYTFAP	CBL_PTK	100:108	Mutation altering degron motif	0.5641
p.P101S	RKO	large intestine	COSMIC	PPRY	ITCH	101:104	Mutation altering degron motif	0.6752
p.G243S	ROS-50	haematopoietic and lymphoid tissue	COSMIC	PTPLQS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.0833
p.R256Q	ROS-50	haematopoietic and lymphoid tissue	COSMIC	PTPLQS	DEG_SCF_FBW7_1	252:257	Mutation altering degron motif	0.7329

Kaplan plot for PDLIM7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDLIM7

UniProt ID: Q9NR12

Entrez ID: 9260

Protein name: PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDLIM7 in