DegronMD

Uniprot ID: Q9NR12

Source protein: PDZ and LIM domain protein 7

Source gene: PDLIM7

Class: DEG_SCF_FBW7_1

Location: 252:257

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 81.7167

COIL: 0.8243

CONS_SCORE: 0.556

DSS_SCORE: 0.6623

HELIX: 0.151

FCONS_SCORE: 1.0381

RIG_SCORE: 0.6845

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R258L	TCGA-55-8302	LUAD	TCGA	PTPLQS	DEG_SCF_FBW7_1	0.3056
p.R245W	TCGA-AX-A2HD	UCEC	TCGA	PTPLQS	DEG_SCF_FBW7_1	0.1389
p.H246R	DO233672	GACA	ICGC	PTPLQS	DEG_SCF_FBW7_1	0.1667
p.L263M	DO229035	LICA	ICGC	PTPLQS	DEG_SCF_FBW7_1	0.1667
p.R246W	DO27120	LUSC	ICGC	PTPLQS	DEG_SCF_FBW7_1	0.1667
p.R246W	DO51524	PACA	ICGC	PTPLQS	DEG_SCF_FBW7_1	0.1667
p.S244G	DO50127	STAD	ICGC	PTPLQS	DEG_SCF_FBW7_1	0.5556
p.V242G	ACH-002680	Brain Cancer	CCLE	PTPLQS	DEG_SCF_FBW7_1	0.0556
p.G252W	GP5d	large_intestine	COSMIC	PTPLQS	DEG_SCF_FBW7_1	0.7825
p.G243S	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	PTPLQS	DEG_SCF_FBW7_1	0.0833
p.R256Q	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	PTPLQS	DEG_SCF_FBW7_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04725	Transducin-like enhancer protein 2	DEG_SCF_FBW7_1	8:13	PTPLQS	FBXW7	0.914	More...
Q9NR12	PDZ and LIM domain protein 7	DEG_SCF_FBW7_1	252:257	PTPLQS	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons