DegronMD - Q04725(TLE2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P348S	TCGA-78-7155	LUAD	TCGA	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.6752
p.S359I	TCGA-AJ-A3EK	UCEC	TCGA	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1389
p.G14D	TCGA-BR-4256	STAD	TCGA	PTPLQS	DEG_SCF_FBW7_1	8:13	Mutation rewiring degron network	0.3056
p.Q4H	TCGA-CV-7238	HNSC	TCGA	PTPLQS	DEG_SCF_FBW7_1	8:13	Mutation rewiring degron network	0.2222
p.Q4H	DO15246	HNSC	ICGC	PTPLQS	DEG_SCF_FBW7_1	8:13	Mutation rewiring degron network	0.2222
p.P349T	DO229032	LICA	ICGC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.7031
p.P349S	DO23590	LUAD	ICGC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.6752
p.L346V	DO230934	LUSC	ICGC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2778
p.L346V	DO224581	LUSC	ICGC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2778
p.S13F	DO220877	MELA	ICGC	PTPLQS	DEG_SCF_FBW7_1	8:13	Mutation altering degron motif	0.7982
p.P12H	DO46657	PAAD	ICGC	PTPLQS	DEG_SCF_FBW7_1	8:13	Mutation altering degron motif	0.7694
p.N16D	DO232761	PBCA	ICGC	PTPLQS	DEG_SCF_FBW7_1	8:13	Mutation rewiring degron network	0.25
p.G5E	DO229462	SKCA	ICGC	PTPLQS	DEG_SCF_FBW7_1	8:13	Mutation rewiring degron network	0.25
p.P23L	DO37468	SKCM	ICGC	PTPLQS	DEG_SCF_FBW7_1	8:13	Mutation rewiring degron network	0.0556
p.A339V	DO229275	THCA	ICGC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0833
p.A339V	SIDM01059	Melanoma	GDSC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0833
p.A339V	IPC-298	skin	COSMIC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0833
p.P3S	DO229227	THCA	ICGC	PTPLQS	DEG_SCF_FBW7_1	8:13	Mutation rewiring degron network	0.1944
p.R6K	DO229234	THCA	ICGC	PTPLQS	DEG_SCF_FBW7_1	8:13	Mutation rewiring degron network	0.2778
p.P18L	DO48177	UCEC	ICGC	PTPLQS	DEG_SCF_FBW7_1	8:13	Mutation substituting flanking lysine	0.3056
p.S360I	DO41584	UCEC	ICGC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1111
p.S360N	SIDM00655	Other Solid Cancers	GDSC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1111
p.S360N	NCCIT	testis	COSMIC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1111
p.S357P	ACH-000037	Sarcoma	CCLE	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1944
p.S357P	S-117	soft tissue	COSMIC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1944
p.S359N	ACH-001578	Embryonal Cancer	CCLE	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1389
p.S359N	NCCIT	testis	COSMIC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1389
p.T342I	SW684	soft tissue	COSMIC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667
p.A352V	IPC-298	skin	COSMIC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation altering degron motif	0.6936
p.E10D	BC-3	haematopoietic and lymphoid tissue	COSMIC	PTPLQS	DEG_SCF_FBW7_1	8:13	Mutation altering degron motif	0.6758
p.A338V	IPC-298	skin	COSMIC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.0556
p.G354S	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.2778
p.V6D	COR-L321	NS	COSMIC	PTPLQS	DEG_SCF_FBW7_1	8:13	Mutation rewiring degron network	0.2778
p.S358P	S-117	soft tissue	COSMIC	PFTTS	DEG_SPOP_SBC_1	348:352	Mutation rewiring degron network	0.1667

Kaplan plot for TLE2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TLE2

UniProt ID: Q04725

Entrez ID: 7089

Protein name: Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TLE2 in