DegronMD

Uniprot ID: Q04725

Source protein: Transducin-like enhancer protein 2

Source gene: TLE2

Class: DEG_SPOP_SBC_1

Location: 348:352

E3 ligase: SPOP

DEGRON score: 0.6788

ASA_SCORE: 41.48

COIL: 0.805

CONS_SCORE: 0.4535

DSS_SCORE: 0.2917

HELIX: 0.1072

FCONS_SCORE: 1.0701

RIG_SCORE: 0.7193

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P348S	TCGA-78-7155	LUAD	TCGA	PFTTS	DEG_SPOP_SBC_1	0.6752
p.S359I	TCGA-AJ-A3EK	UCEC	TCGA	PFTTS	DEG_SPOP_SBC_1	0.1389
p.P349T	DO229032	LICA	ICGC	PFTTS	DEG_SPOP_SBC_1	0.7031
p.P349S	DO23590	LUAD	ICGC	PFTTS	DEG_SPOP_SBC_1	0.6752
p.L346V	DO230934	LUSC	ICGC	PFTTS	DEG_SPOP_SBC_1	0.2778
p.L346V	DO224581	LUSC	ICGC	PFTTS	DEG_SPOP_SBC_1	0.2778
p.A339V	DO229275	THCA	ICGC	PFTTS	DEG_SPOP_SBC_1	0.0833
p.A339V	SIDM01059	Melanoma	GDSC	PFTTS	DEG_SPOP_SBC_1	0.0833
p.A339V	IPC-298	skin	COSMIC	PFTTS	DEG_SPOP_SBC_1	0.0833
p.S360I	DO41584	UCEC	ICGC	PFTTS	DEG_SPOP_SBC_1	0.1111
p.S360N	SIDM00655	Other Solid Cancers	GDSC	PFTTS	DEG_SPOP_SBC_1	0.1111
p.S360N	NCCIT	testis	COSMIC	PFTTS	DEG_SPOP_SBC_1	0.1111
p.S357P	ACH-000037	Sarcoma	CCLE	PFTTS	DEG_SPOP_SBC_1	0.1944
p.S357P	S-117	soft_tissue	COSMIC	PFTTS	DEG_SPOP_SBC_1	0.1944
p.S359N	ACH-001578	Embryonal Cancer	CCLE	PFTTS	DEG_SPOP_SBC_1	0.1389
p.S359N	NCCIT	testis	COSMIC	PFTTS	DEG_SPOP_SBC_1	0.1389
p.T342I	SW684	soft_tissue	COSMIC	PFTTS	DEG_SPOP_SBC_1	0.1667
p.A352V	IPC-298	skin	COSMIC	PFTTS	DEG_SPOP_SBC_1	0.6936
p.A338V	IPC-298	skin	COSMIC	PFTTS	DEG_SPOP_SBC_1	0.0556
p.G354S	WSU-DLCL2	haematopoietic_and_lymphoid_tissue	COSMIC	PFTTS	DEG_SPOP_SBC_1	0.2778
p.S358P	S-117	soft_tissue	COSMIC	PFTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35548	Homeobox protein MSX-2	DEG_SPOP_SBC_1	148:152	PFTTS	SPOP	0.9227	More...
Q04725	Transducin-like enhancer protein 2	DEG_SPOP_SBC_1	348:352	PFTTS	SPOP	0.6788	More...
Q9H8N7	Zinc finger protein 395	DEG_SPOP_SBC_1	45:49	PFTTS	SPOP	0.8251	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons