DegronMD - P35548(MSX2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R137K	TCGA-21-1079	LUSC	TCGA	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1111
p.R137K	DO26846	LUSC	ICGC	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1111
p.R137M	TCGA-46-6026	LUSC	TCGA	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1111
p.R137M	DO26740	LUSC	ICGC	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1111
p.R146H	TCGA-AA-A022	COAD	TCGA	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.7133
p.R146H	TCGA-F4-6703	COAD	TCGA	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.7133
p.R146H	TCGA-G4-6588	COAD	TCGA	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.7133
p.R146H	DO10647	COAD	ICGC	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.7133
p.R146H	DO10140	COAD	ICGC	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.7133
p.R146H	DO9908	COAD	ICGC	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.7133
p.R146H	DO228138	PBCA	ICGC	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.7133
p.A156T	TCGA-AJ-A3EL	UCEC	TCGA	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1944
p.A156T	TCGA-AJ-A3EL	UCEC	TCGA	PFTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2222
p.A156T	DO41542	UCEC	ICGC	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1944
p.A156T	DO41542	UCEC	ICGC	PFTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.2222
p.F149L	TCGA-BG-A222	UCEC	TCGA	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.587
p.F149L	TCGA-BG-A222	UCEC	TCGA	PFTTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.587
p.F149L	DO42977	UCEC	ICGC	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.587
p.F149L	DO42977	UCEC	ICGC	PFTTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.587
p.P145L	TCGA-CM-5861	COAD	TCGA	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.6471
p.P145L	DO7918	COAD	ICGC	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.6471
p.E158K	TCGA-FG-6690	LGG	TCGA	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.E158K	TCGA-FG-6690	LGG	TCGA	PFTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1667
p.E158K	DO22141	LGG	ICGC	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation rewiring degron network	0.1389
p.E158K	DO22141	LGG	ICGC	PFTTS	DEG_SPOP_SBC_1	148:152	Mutation rewiring degron network	0.1667
p.T147M	TCGA-J4-AATZ	PRAD	TCGA	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.7423
p.T147M	DO219261	PRAD	ICGC	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.7423
p.K160N	DO229028	LICA	ICGC	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation substituting flanking lysine	0.1944
p.K160N	DO229028	LICA	ICGC	PFTTS	DEG_SPOP_SBC_1	148:152	Mutation substituting flanking lysine	0.2222
p.S152F	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PFTTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7982
p.S152F	ACH-000823	Esophageal Cancer	CCLE	PFTTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7982
p.S152F	KYSE-140	oesophagus	COSMIC	PFTTS	DEG_SPOP_SBC_1	148:152	Mutation altering degron motif	0.7982
p.R146S	SIDM00014	Colorectal Carcinoma	GDSC	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.6316
p.R146S	LIM1215	large intestine	COSMIC	PRTPFTT	DEG_SCF_FBW7_1	145:151	Mutation altering degron motif	0.6316

Kaplan plot for MSX2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MSX2

UniProt ID: P35548

Entrez ID: 4488

Protein name: Homeobox protein MSX-2 (Homeobox protein Hox-8)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MSX2 in