DegronMD

Uniprot ID: P35548

Source protein: Homeobox protein MSX-2

Source gene: MSX2

Class: DEG_SPOP_SBC_1

Location: 148:152

E3 ligase: SPOP

DEGRON score: 0.9227

ASA_SCORE: 59.28

COIL: 0.5684

CONS_SCORE: 0.8571

DSS_SCORE: 0.5689

HELIX: 0.4108

FCONS_SCORE: 0.9953

RIG_SCORE: 0.7874

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A156T	TCGA-AJ-A3EL	UCEC	TCGA	PFTTS	DEG_SPOP_SBC_1	0.2222
p.A156T	DO41542	UCEC	ICGC	PFTTS	DEG_SPOP_SBC_1	0.2222
p.F149L	TCGA-BG-A222	UCEC	TCGA	PFTTS	DEG_SPOP_SBC_1	0.587
p.F149L	DO42977	UCEC	ICGC	PFTTS	DEG_SPOP_SBC_1	0.587
p.E158K	TCGA-FG-6690	LGG	TCGA	PFTTS	DEG_SPOP_SBC_1	0.1667
p.E158K	DO22141	LGG	ICGC	PFTTS	DEG_SPOP_SBC_1	0.1667
p.K160N	DO229028	LICA	ICGC	PFTTS	DEG_SPOP_SBC_1	0.2222
p.S152F	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PFTTS	DEG_SPOP_SBC_1	0.7982
p.S152F	ACH-000823	Esophageal Cancer	CCLE	PFTTS	DEG_SPOP_SBC_1	0.7982
p.S152F	KYSE-140	oesophagus	COSMIC	PFTTS	DEG_SPOP_SBC_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35548	Homeobox protein MSX-2	DEG_SPOP_SBC_1	148:152	PFTTS	SPOP	0.9227	More...
Q04725	Transducin-like enhancer protein 2	DEG_SPOP_SBC_1	348:352	PFTTS	SPOP	0.6788	More...
Q9H8N7	Zinc finger protein 395	DEG_SPOP_SBC_1	45:49	PFTTS	SPOP	0.8251	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons