DegronMD

Uniprot ID: Q9H8N7

Source protein: Zinc finger protein 395

Source gene: ZNF395

Class: DEG_SPOP_SBC_1

Location: 45:49

E3 ligase: SPOP

DEGRON score: 0.8251

ASA_SCORE: 46.38

COIL: 0.416

CONS_SCORE: 0.4142

DSS_SCORE: 0.7614

HELIX: 0.0378

FCONS_SCORE: 1.0916

RIG_SCORE: 0.6244

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A42T	TCGA-AD-6889	COAD	TCGA	PFTTS	DEG_SPOP_SBC_1	0.25
p.A42T	TCGA-EI-6507	READ	TCGA	PFTTS	DEG_SPOP_SBC_1	0.25
p.A42T	DO8463	COAD	ICGC	PFTTS	DEG_SPOP_SBC_1	0.25
p.A42T	DO232732	PBCA	ICGC	PFTTS	DEG_SPOP_SBC_1	0.25
p.A42T	DO36675	READ	ICGC	PFTTS	DEG_SPOP_SBC_1	0.25
p.T47I	TCGA-B5-A3FA	UCEC	TCGA	PFTTS	DEG_SPOP_SBC_1	0.7078
p.T47I	DO52402	UCEC	ICGC	PFTTS	DEG_SPOP_SBC_1	0.7078
p.S49Y	TCGA-D3-A3C8	SKCM	TCGA	PFTTS	DEG_SPOP_SBC_1	0.712
p.S49Y	DO47636	SKCM	ICGC	PFTTS	DEG_SPOP_SBC_1	0.712
p.G40W	TCGA-EE-A2M5	SKCM	TCGA	PFTTS	DEG_SPOP_SBC_1	0.1944
p.G40W	DO37425	SKCM	ICGC	PFTTS	DEG_SPOP_SBC_1	0.1944
p.S49C	TCGA-XF-A9T8	BLCA	TCGA	PFTTS	DEG_SPOP_SBC_1	0.7541
p.S49C	DO51927	BLCA	ICGC	PFTTS	DEG_SPOP_SBC_1	0.7541
p.T47N	DO229018	LICA	ICGC	PFTTS	DEG_SPOP_SBC_1	0.7055
p.P53H	DO229018	LICA	ICGC	PFTTS	DEG_SPOP_SBC_1	0.2222
p.Q44K	DO231201	LUSC	ICGC	PFTTS	DEG_SPOP_SBC_1	0.3056
p.P53L	DO222595	MELA	ICGC	PFTTS	DEG_SPOP_SBC_1	0.2222
p.Q55R	DO229264	THCA	ICGC	PFTTS	DEG_SPOP_SBC_1	0.1667
p.P43L	SIDM00007	Other Solid Cancers	GDSC	PFTTS	DEG_SPOP_SBC_1	0.2778
p.P43L	ACH-001550	Skin Cancer	CCLE	PFTTS	DEG_SPOP_SBC_1	0.2778
p.P43L	MCC13	skin	COSMIC	PFTTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35548	Homeobox protein MSX-2	DEG_SPOP_SBC_1	148:152	PFTTS	SPOP	0.9227	More...
Q04725	Transducin-like enhancer protein 2	DEG_SPOP_SBC_1	348:352	PFTTS	SPOP	0.6788	More...
Q9H8N7	Zinc finger protein 395	DEG_SPOP_SBC_1	45:49	PFTTS	SPOP	0.8251	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons