DegronMD - Q9H8N7(ZNF395)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T360S	TCGA-22-5481	LUSC	TCGA	PAPTPSMT	DEG_SCF_FBW7_1	353:360	Mutation altering degron motif	0.6005
p.T360S	DO27160	LUSC	ICGC	PAPTPSMT	DEG_SCF_FBW7_1	353:360	Mutation altering degron motif	0.6005
p.K63E	TCGA-55-6968	LUAD	TCGA	APSTS	DEG_SPOP_SBC_1	64:68	Mutation blocking ubiquitination signal	0.75
p.K63E	DO23759	LUAD	ICGC	APSTS	DEG_SPOP_SBC_1	64:68	Mutation blocking ubiquitination signal	0.75
p.G219S	TCGA-AA-3815	COAD	TCGA	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation rewiring degron network	0.2778
p.G219S	DO9924	COAD	ICGC	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation rewiring degron network	0.2778
p.A42T	TCGA-AD-6889	COAD	TCGA	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.25
p.A42T	TCGA-EI-6507	READ	TCGA	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.25
p.A42T	DO8463	COAD	ICGC	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.25
p.A42T	DO232732	PBCA	ICGC	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.25
p.A42T	DO36675	READ	ICGC	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.25
p.S68L	TCGA-AX-A2HC	UCEC	TCGA	APSTS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.7667
p.S68L	DO41572	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.7667
p.T47I	TCGA-B5-A3FA	UCEC	TCGA	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.7078
p.T47I	DO52402	UCEC	ICGC	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.7078
p.T356A	TCGA-BS-A0UF	UCEC	TCGA	PAPTPSMT	DEG_SCF_FBW7_1	353:360	Mutation altering degron motif	0.7139
p.T356A	DO41488	UCEC	ICGC	PAPTPSMT	DEG_SCF_FBW7_1	353:360	Mutation altering degron motif	0.7139
p.S49Y	TCGA-D3-A3C8	SKCM	TCGA	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.712
p.S49Y	DO47636	SKCM	ICGC	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.712
p.P346S	TCGA-D3-A8GI	SKCM	TCGA	VPGTPTSE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.5641
p.P346S	DO50284	SKCM	ICGC	VPGTPTSE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.5641
p.G213D	TCGA-D7-A4YY	STAD	TCGA	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation altering degron motif	0.7198
p.G213D	DO225346	BRCA	ICGC	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation altering degron motif	0.7198
p.G213D	DO47733	STAD	ICGC	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation altering degron motif	0.7198
p.G213S	TCGA-DF-A2KU	UCEC	TCGA	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation altering degron motif	0.6993
p.G213S	DO223286	UCEC	ICGC	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation altering degron motif	0.6993
p.G213S	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation altering degron motif	0.6993
p.G213S	ACH-002311	Esophageal Cancer	CCLE	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation altering degron motif	0.6993
p.G213S	TE-12	oesophagus	COSMIC	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation altering degron motif	0.6993
p.G40W	TCGA-EE-A2M5	SKCM	TCGA	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1944
p.G40W	DO37425	SKCM	ICGC	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1944
p.P346L	TCGA-FW-A3R5	SKCM	TCGA	VPGTPTSE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.6471
p.P346L	DO232973	PEME	ICGC	VPGTPTSE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.6471
p.P346L	DO37406	SKCM	ICGC	VPGTPTSE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.6471
p.L70P	TCGA-G3-A25V	LIHC	TCGA	APSTS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.2778
p.L70P	DO22866	LIHC	ICGC	APSTS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.2778
p.S49C	TCGA-XF-A9T8	BLCA	TCGA	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.7541
p.S49C	DO51927	BLCA	ICGC	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.7541
p.T350P	DO48405	BLCA	ICGC	VPGTPTSE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.5919
p.T350P	ACH-000555	Kidney Cancer	CCLE	VPGTPTSE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.5919
p.T350P	ACH-000713	Ovarian Cancer	CCLE	VPGTPTSE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.5919
p.T350P	ACH-000846	Head and Neck Cancer	CCLE	VPGTPTSE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.5919
p.T350P	ACH-002223	Brain Cancer	CCLE	VPGTPTSE	DEG_SCF_FBW7_2	345:352	Mutation altering degron motif	0.5919
p.T67N	DO233864	GACA	ICGC	APSTS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.7055
p.P370T	DO228974	LICA	ICGC	PAPTPSMT	DEG_SCF_FBW7_1	353:360	Mutation rewiring degron network	0.0556
p.P77T	DO228971	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0833
p.T47N	DO229018	LICA	ICGC	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation altering degron motif	0.7055
p.P53H	DO229018	LICA	ICGC	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.2222
p.P353T	DO229019	LICA	ICGC	PAPTPSMT	DEG_SCF_FBW7_1	353:360	Mutation altering degron motif	0.7031
p.A339S	DO48706	LIRI	ICGC	VPGTPTSE	DEG_SCF_FBW7_2	345:352	Mutation rewiring degron network	0.1667
p.Q44K	DO231201	LUSC	ICGC	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.3056
p.P53L	DO222595	MELA	ICGC	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.2222
p.A64D	DO232761	PBCA	ICGC	APSTS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.7793
p.Q55R	DO229264	THCA	ICGC	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.1667
p.Q55R	DO229264	THCA	ICGC	APSTS	DEG_SPOP_SBC_1	64:68	Mutation rewiring degron network	0.0833
p.P43L	SIDM00007	Other Solid Cancers	GDSC	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.2778
p.P43L	ACH-001550	Skin Cancer	CCLE	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.2778
p.P43L	MCC13	skin	COSMIC	PFTTS	DEG_SPOP_SBC_1	45:49	Mutation rewiring degron network	0.2778
p.L364V	SIDM00592	Oral Cavity Carcinoma	GDSC	PAPTPSMT	DEG_SCF_FBW7_1	353:360	Mutation rewiring degron network	0.2222
p.L364V	ACH-002244	Head and Neck Cancer	CCLE	PAPTPSMT	DEG_SCF_FBW7_1	353:360	Mutation rewiring degron network	0.2222
p.L364V	HO-1-N-1	salivary gland	COSMIC	PAPTPSMT	DEG_SCF_FBW7_1	353:360	Mutation rewiring degron network	0.2222
p.P65T	SIDM00238	Ovarian Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.5919
p.P65T	ACH-000947	Ovarian Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.5919
p.P65T	OVK-18	ovary	COSMIC	APSTS	DEG_SPOP_SBC_1	64:68	Mutation altering degron motif	0.5919
p.P202Q	SIDM00596	Endometrial Carcinoma	GDSC	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation rewiring degron network	0.0833
p.P202Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation rewiring degron network	0.0833
p.P202Q	HEC-1	endometrium	COSMIC	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation rewiring degron network	0.0833
p.G219D	SIDM00251	Gastric Carcinoma	GDSC	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation rewiring degron network	0.2778
p.G219D	ACH-000949	Gastric Cancer	CCLE	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation rewiring degron network	0.2778
p.G219D	TGBC11TKB	stomach	COSMIC	DSGSSTT	DEG_SCF_TRCP1_1	211:217	Mutation rewiring degron network	0.2778
p.M359R	ACH-000707	Lymphoma	CCLE	PAPTPSMT	DEG_SCF_FBW7_1	353:360	Mutation altering degron motif	0.7521
p.M359R	ACH-002252	Lymphoma	CCLE	PAPTPSMT	DEG_SCF_FBW7_1	353:360	Mutation altering degron motif	0.7521
p.M359R	JiyoyeP-2003	haematopoietic and lymphoid tissue	COSMIC	PAPTPSMT	DEG_SCF_FBW7_1	353:360	Mutation altering degron motif	0.7521
p.P355H	ACH-001610	Brain Cancer	CCLE	PAPTPSMT	DEG_SCF_FBW7_1	353:360	Mutation altering degron motif	0.6583

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF395

UniProt ID: Q9H8N7

Entrez ID: 55893

Protein name: Zinc finger protein 395 (HD-regulating factor 2) (HDRF-2) (Huntington disease gene regulatory region-binding protein 2) (HD gene regulatory region-binding protein 2) (HDBP-2) (Papillomavirus regulatory factor 1) (PRF-1) (Papillomavirus-binding factor)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZNF395 in