DegronMD

Uniprot ID: Q9H8N7

Source protein: Zinc finger protein 395

Source gene: ZNF395

Class: DEG_SCF_FBW7_1

Location: 353:360

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 77.8625

COIL: 0.9179

CONS_SCORE: 0.4577

DSS_SCORE: 0.74

HELIX: 0.051

FCONS_SCORE: 1.0974

RIG_SCORE: 0.5837

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M359R	ACH-000707	Lymphoma	CCLE	PAPTPSMT	DEG_SCF_FBW7_1	0.7521
p.M359R	ACH-002252	Lymphoma	CCLE	PAPTPSMT	DEG_SCF_FBW7_1	0.7521
p.M359R	JiyoyeP-2003	haematopoietic_and_lymphoid_tissue	COSMIC	PAPTPSMT	DEG_SCF_FBW7_1	0.7521
p.T356A	TCGA-BS-A0UF	UCEC	TCGA	PAPTPSMT	DEG_SCF_FBW7_1	0.7139
p.T356A	DO41488	UCEC	ICGC	PAPTPSMT	DEG_SCF_FBW7_1	0.7139
p.P353T	DO229019	LICA	ICGC	PAPTPSMT	DEG_SCF_FBW7_1	0.7031
p.P355H	ACH-001610	Brain Cancer	CCLE	PAPTPSMT	DEG_SCF_FBW7_1	0.6583
p.T360S	TCGA-22-5481	LUSC	TCGA	PAPTPSMT	DEG_SCF_FBW7_1	0.6005
p.T360S	DO27160	LUSC	ICGC	PAPTPSMT	DEG_SCF_FBW7_1	0.6005
p.L364V	SIDM00592	Oral Cavity Carcinoma	GDSC	PAPTPSMT	DEG_SCF_FBW7_1	0.2222
p.L364V	ACH-002244	Head and Neck Cancer	CCLE	PAPTPSMT	DEG_SCF_FBW7_1	0.2222
p.L364V	HO-1-N-1	salivary_gland	COSMIC	PAPTPSMT	DEG_SCF_FBW7_1	0.2222
p.P370T	DO228974	LICA	ICGC	PAPTPSMT	DEG_SCF_FBW7_1	0.0556

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8N7	Zinc finger protein 395	DEG_SCF_FBW7_1	353:360	PAPTPSMT	FBXW7	0.9971	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons