DegronMD

Uniprot ID: Q9H8N7

Source protein: Zinc finger protein 395

Source gene: ZNF395

Class: DEG_SCF_FBW7_2

Location: 345:352

E3 ligase: FBXW7

DEGRON score: 0.9346

ASA_SCORE: 85.7125

COIL: 0.958

CONS_SCORE: 0.407

DSS_SCORE: 0.695

HELIX: 0.0116

FCONS_SCORE: 1.0467

RIG_SCORE: 0.5588

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P346S	TCGA-D3-A8GI	SKCM	TCGA	VPGTPTSE	DEG_SCF_FBW7_2	0.5641
p.P346S	DO50284	SKCM	ICGC	VPGTPTSE	DEG_SCF_FBW7_2	0.5641
p.P346L	TCGA-FW-A3R5	SKCM	TCGA	VPGTPTSE	DEG_SCF_FBW7_2	0.6471
p.P346L	DO232973	PEME	ICGC	VPGTPTSE	DEG_SCF_FBW7_2	0.6471
p.P346L	DO37406	SKCM	ICGC	VPGTPTSE	DEG_SCF_FBW7_2	0.6471
p.T350P	DO48405	BLCA	ICGC	VPGTPTSE	DEG_SCF_FBW7_2	0.5919
p.T350P	ACH-000555	Kidney Cancer	CCLE	VPGTPTSE	DEG_SCF_FBW7_2	0.5919
p.T350P	ACH-000713	Ovarian Cancer	CCLE	VPGTPTSE	DEG_SCF_FBW7_2	0.5919
p.T350P	ACH-000846	Head and Neck Cancer	CCLE	VPGTPTSE	DEG_SCF_FBW7_2	0.5919
p.T350P	ACH-002223	Brain Cancer	CCLE	VPGTPTSE	DEG_SCF_FBW7_2	0.5919
p.A339S	DO48706	LIRI	ICGC	VPGTPTSE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8N7	Zinc finger protein 395	DEG_SCF_FBW7_2	345:352	VPGTPTSE	FBXW7	0.9346	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons