DegronMD

Uniprot ID: Q9H8N7

Source protein: Zinc finger protein 395

Source gene: ZNF395

Class: DEG_SCF_TRCP1_1

Location: 211:217

E3 ligase: BTRC

DEGRON score: 0.9946

ASA_SCORE: 50.1429

COIL: 0.8479

CONS_SCORE: 0.5162

DSS_SCORE: 0.6317

HELIX: 0.0723

FCONS_SCORE: 1.4779

RIG_SCORE: 0.5247

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G219S	TCGA-AA-3815	COAD	TCGA	DSGSSTT	DEG_SCF_TRCP1_1	0.2778
p.G219S	DO9924	COAD	ICGC	DSGSSTT	DEG_SCF_TRCP1_1	0.2778
p.G213D	TCGA-D7-A4YY	STAD	TCGA	DSGSSTT	DEG_SCF_TRCP1_1	0.7198
p.G213D	DO225346	BRCA	ICGC	DSGSSTT	DEG_SCF_TRCP1_1	0.7198
p.G213D	DO47733	STAD	ICGC	DSGSSTT	DEG_SCF_TRCP1_1	0.7198
p.G213S	TCGA-DF-A2KU	UCEC	TCGA	DSGSSTT	DEG_SCF_TRCP1_1	0.6993
p.G213S	DO223286	UCEC	ICGC	DSGSSTT	DEG_SCF_TRCP1_1	0.6993
p.G213S	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	DSGSSTT	DEG_SCF_TRCP1_1	0.6993
p.G213S	ACH-002311	Esophageal Cancer	CCLE	DSGSSTT	DEG_SCF_TRCP1_1	0.6993
p.G213S	TE-12	oesophagus	COSMIC	DSGSSTT	DEG_SCF_TRCP1_1	0.6993
p.P202Q	SIDM00596	Endometrial Carcinoma	GDSC	DSGSSTT	DEG_SCF_TRCP1_1	0.0833
p.P202Q	ACH-001517	Endometrial/Uterine Cancer	CCLE	DSGSSTT	DEG_SCF_TRCP1_1	0.0833
p.P202Q	HEC-1	endometrium	COSMIC	DSGSSTT	DEG_SCF_TRCP1_1	0.0833
p.G219D	SIDM00251	Gastric Carcinoma	GDSC	DSGSSTT	DEG_SCF_TRCP1_1	0.2778
p.G219D	ACH-000949	Gastric Cancer	CCLE	DSGSSTT	DEG_SCF_TRCP1_1	0.2778
p.G219D	TGBC11TKB	stomach	COSMIC	DSGSSTT	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8N7	Zinc finger protein 395	DEG_SCF_TRCP1_1	211:217	DSGSSTT	BTRC	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons