DegronMD

Uniprot ID: P35548

Source protein: Homeobox protein MSX-2

Source gene: MSX2

Class: DEG_SCF_FBW7_1

Location: 145:151

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 61.0857

COIL: 0.7947

CONS_SCORE: 0.9052

DSS_SCORE: 0.6037

HELIX: 0.1593

FCONS_SCORE: 1.0831

RIG_SCORE: 0.7398

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R137K	TCGA-21-1079	LUSC	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.1111
p.R137K	DO26846	LUSC	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.1111
p.R137M	TCGA-46-6026	LUSC	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.1111
p.R137M	DO26740	LUSC	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.1111
p.R146H	TCGA-AA-A022	COAD	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.7133
p.R146H	TCGA-F4-6703	COAD	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.7133
p.R146H	TCGA-G4-6588	COAD	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.7133
p.R146H	DO10647	COAD	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.7133
p.R146H	DO10140	COAD	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.7133
p.R146H	DO9908	COAD	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.7133
p.R146H	DO228138	PBCA	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.7133
p.A156T	TCGA-AJ-A3EL	UCEC	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.1944
p.A156T	DO41542	UCEC	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.1944
p.F149L	TCGA-BG-A222	UCEC	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.587
p.F149L	DO42977	UCEC	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.587
p.P145L	TCGA-CM-5861	COAD	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.6471
p.P145L	DO7918	COAD	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.6471
p.E158K	TCGA-FG-6690	LGG	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.1389
p.E158K	DO22141	LGG	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.1389
p.T147M	TCGA-J4-AATZ	PRAD	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.7423
p.T147M	DO219261	PRAD	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.7423
p.K160N	DO229028	LICA	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.1944
p.R146S	SIDM00014	Colorectal Carcinoma	GDSC	PRTPFTT	DEG_SCF_FBW7_1	0.6316
p.R146S	LIM1215	large_intestine	COSMIC	PRTPFTT	DEG_SCF_FBW7_1	0.6316

DegronMD: protein-targeted degradation, mutation and drug response to degrons