DegronMD

Uniprot ID: P28360

Source protein: Homeobox protein MSX-1

Source gene: MSX1

Class: DEG_SCF_FBW7_1

Location: 175:181

E3 ligase: FBXW7

DEGRON score: 0.9687

ASA_SCORE: 57.1571

COIL: 0.7909

CONS_SCORE: 0.8227

DSS_SCORE: 0.5806

HELIX: 0.1606

FCONS_SCORE: 0.9417

RIG_SCORE: 0.7506

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R173C	TCGA-06-5416	GBM	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.2778
p.R173C	TCGA-L5-A4OI	ESCA	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.2778
p.R173C	DO10880	GBM	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.2778
p.F179C	TCGA-13-1494	OV	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.5996
p.F179C	DO32698	OV	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.5996
p.T177A	TCGA-63-A5MM	LUSC	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.7139
p.T177A	DO219153	LUSC	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.7139
p.R176Q	TCGA-A7-A2KD	BRCA	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.6218
p.R176Q	DO3083	BRCA	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.6218
p.R189H	TCGA-IR-A3LI	CESC	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.1111
p.R189H	DO44400	CESC	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.1111
p.R173H	TCGA-VQ-A91D	STAD	TCGA	PRTPFTT	DEG_SCF_FBW7_1	0.2778
p.R173H	DO233867	GACA	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.2778
p.R173H	DO51783	STAD	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.2778
p.T171M	DO23521	LIRI	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.2222
p.R176W	DO33312	PACA	ICGC	PRTPFTT	DEG_SCF_FBW7_1	0.7523
p.K170R	SIDM00216	Colorectal Carcinoma	GDSC	PRTPFTT	DEG_SCF_FBW7_1	0.3056
p.K170R	ACH-000989	Colon/Colorectal Cancer	CCLE	PRTPFTT	DEG_SCF_FBW7_1	0.3056
p.K170R	SNU-175	large_intestine	COSMIC	PRTPFTT	DEG_SCF_FBW7_1	0.3056
p.T180I	SIDM00233	T-Lymphoblastic Leukemia	GDSC	PRTPFTT	DEG_SCF_FBW7_1	0.7078
p.T180I	ACH-002058	Leukemia	CCLE	PRTPFTT	DEG_SCF_FBW7_1	0.7078
p.T180I	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRTPFTT	DEG_SCF_FBW7_1	0.7078
p.P178S	SIDM00780	Colorectal Carcinoma	GDSC	PRTPFTT	DEG_SCF_FBW7_1	0.6752
p.P178S	ACH-000967	Colon/Colorectal Cancer	CCLE	PRTPFTT	DEG_SCF_FBW7_1	0.6752
p.R167P	ACH-000900	Lung Cancer	CCLE	PRTPFTT	DEG_SCF_FBW7_1	0.1111
p.R167P	NCI-H23	lung	COSMIC	PRTPFTT	DEG_SCF_FBW7_1	0.1111
p.A182V	ACH-001278	Ovarian Cancer	CCLE	PRTPFTT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28360	Homeobox protein MSX-1	DEG_SCF_FBW7_1	175:181	PRTPFTT	FBXW7	0.9687	More...
P35548	Homeobox protein MSX-2	DEG_SCF_FBW7_1	145:151	PRTPFTT	FBXW7	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTPFTT

Degron related mutations and impact score

Drug responses associated with MSX1 mutations

All proteins holding degron of PRTPFTT