DegronMD

Uniprot ID: Q04725

Source protein: Transducin-like enhancer protein 2

Source gene: TLE2

Class: DEG_SCF_FBW7_1

Location: 8:13

E3 ligase: FBXW7

DEGRON score: 0.914

ASA_SCORE: 80.9

COIL: 0.9422

CONS_SCORE: 0.4317

DSS_SCORE: 0.552

HELIX: 0.024

FCONS_SCORE: 0.9722

RIG_SCORE: 0.658

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G14D	TCGA-BR-4256	STAD	TCGA	PTPLQS	DEG_SCF_FBW7_1	0.3056
p.Q4H	TCGA-CV-7238	HNSC	TCGA	PTPLQS	DEG_SCF_FBW7_1	0.2222
p.Q4H	DO15246	HNSC	ICGC	PTPLQS	DEG_SCF_FBW7_1	0.2222
p.S13F	DO220877	MELA	ICGC	PTPLQS	DEG_SCF_FBW7_1	0.7982
p.P12H	DO46657	PAAD	ICGC	PTPLQS	DEG_SCF_FBW7_1	0.7694
p.N16D	DO232761	PBCA	ICGC	PTPLQS	DEG_SCF_FBW7_1	0.25
p.G5E	DO229462	SKCA	ICGC	PTPLQS	DEG_SCF_FBW7_1	0.25
p.P23L	DO37468	SKCM	ICGC	PTPLQS	DEG_SCF_FBW7_1	0.0556
p.P3S	DO229227	THCA	ICGC	PTPLQS	DEG_SCF_FBW7_1	0.1944
p.R6K	DO229234	THCA	ICGC	PTPLQS	DEG_SCF_FBW7_1	0.2778
p.P18L	DO48177	UCEC	ICGC	PTPLQS	DEG_SCF_FBW7_1	0.3056
p.E10D	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	PTPLQS	DEG_SCF_FBW7_1	0.6758
p.V6D	COR-L321	NS	COSMIC	PTPLQS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q04725	Transducin-like enhancer protein 2	DEG_SCF_FBW7_1	8:13	PTPLQS	FBXW7	0.914	More...
Q9NR12	PDZ and LIM domain protein 7	DEG_SCF_FBW7_1	252:257	PTPLQS	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons