DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DPPRYTFAP
Uniprot ID:
Q9NR12
Source protein:
PDZ and LIM domain protein 7
Source gene:
PDLIM7
Class:
CBL_PTK
Location:
100:108
E3 ligase:
CBL
DEGRON score:
0.9879
ASA_SCORE:
94.6778
COIL:
0.9168
CONS_SCORE:
0.3052
DSS_SCORE:
0.5906
HELIX:
0.0268
FCONS_SCORE:
0.5943
RIG_SCORE:
0.673
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S95P
TCGA-CK-5913
COAD
TCGA
DPPRYTFAP
CBL_PTK
0.6389
p.S95P
DO8826
COAD
ICGC
DPPRYTFAP
CBL_PTK
0.6389
p.Y104N
TCGA-DM-A1HB
COAD
TCGA
DPPRYTFAP
CBL_PTK
0.817
p.S109R
TCGA-ZN-A9VW
MESO
TCGA
DPPRYTFAP
CBL_PTK
0.3056
p.Q92H
DO234150
ESAD
ICGC
DPPRYTFAP
CBL_PTK
0.1111
p.P91L
DO233041
GACA
ICGC
DPPRYTFAP
CBL_PTK
0.0833
p.P91L
ACH-000565
Colon/Colorectal Cancer
CCLE
DPPRYTFAP
CBL_PTK
0.0833
p.A98T
DO232224
PBCA
ICGC
DPPRYTFAP
CBL_PTK
0.2778
p.A99T
SIDM02039
Colorectal Carcinoma
GDSC
DPPRYTFAP
CBL_PTK
0.3056
p.P101L
ACH-000836
Head and Neck Cancer
CCLE
DPPRYTFAP
CBL_PTK
0.6471
p.P118S
ACH-000988
Endometrial/Uterine Cancer
CCLE
DPPRYTFAP
CBL_PTK
0.0556
p.P101S
RKO
large_intestine
COSMIC
DPPRYTFAP
CBL_PTK
0.5641
Drug responses associated with PDLIM7 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DPPRYTFAP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NR12
PDZ and LIM domain protein 7
CBL_PTK
100:108
DPPRYTFAP
CBL
0.9879
More...
