DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPRY
Uniprot ID:
Q14526
Source protein:
Hypermethylated in cancer 1 protein
Source gene:
HIC1
Class:
ITCH
Location:
377:380
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9217
ASA_SCORE:
118.275
COIL:
0.9695
CONS_SCORE:
0.3342
DSS_SCORE:
0.7829
HELIX:
0.0095
FCONS_SCORE:
0.9314
RIG_SCORE:
0.6015
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R379H
DO233855
GACA
ICGC
PPRY
ITCH
0.7133
p.G386W
DO228924
LICA
ICGC
PPRY
ITCH
0.1667
p.G373S
DO229234
THCA
ICGC
PPRY
ITCH
0.2222
p.P376L
SIDM01307
Colorectal Carcinoma
GDSC
PPRY
ITCH
0.3056
p.P378L
ACH-001610
Brain Cancer
CCLE
PPRY
ITCH
0.7582
Drug responses associated with HIC1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPRY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6ND36
Protein FAM83G
ITCH
717:720
PPRY
ITCH,NEDD4
0.7033
More...
O00299
Chloride intracellular channel protein 1
ITCH
90:93
PPRY
ITCH,NEDD4
0.8886
More...
O15247
Chloride intracellular channel protein 2
ITCH
96:99
PPRY
ITCH,NEDD4
0.9319
More...
O43313
ATM interactor
ITCH
287:290
PPRY
ITCH,NEDD4
0.9841
More...
O43435
T-box transcription factor TBX1
ITCH
47:50
PPRY
ITCH,NEDD4
0.9424
More...
O75208
Ubiquinone biosynthesis protein COQ9, mitochondrial
ITCH
79:82
PPRY
ITCH,NEDD4
0.8635
More...
O95793
Double-stranded RNA-binding protein Staufen homolog 1
ITCH
113:116
PPRY
ITCH,NEDD4
0.9455
More...
P05198
Eukaryotic translation initiation factor 2 subunit 1
ITCH
232:235
PPRY
ITCH,NEDD4
0.6815
More...
P21860
Receptor tyrosine-protein kinase erbB-3
ITCH
972:975
PPRY
ITCH,NEDD4
0.9993
More...
P30876
DNA-directed RNA polymerase II subunit RPB2
ITCH
81:84
PPRY
ITCH,NEDD4
0.9176
More...
P53007
Tricarboxylate transport protein, mitochondrial
ITCH
61:64
PPRY
ITCH,NEDD4
0.7489
More...
P54753
Ephrin type-B receptor 3
ITCH
438:441
PPRY
ITCH,NEDD4
0.969
More...
Q09327
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
ITCH
148:151
PPRY
ITCH,NEDD4
0.9144
More...
Q13825
Methylglutaconyl-CoA hydratase, mitochondrial
ITCH
333:336
PPRY
ITCH,NEDD4
0.5278
More...
Q14332
Frizzled-2
ITCH
189:192
PPRY
ITCH,NEDD4
0.5291
More...
Q14526
Hypermethylated in cancer 1 protein
ITCH
377:380
PPRY
ITCH,NEDD4
0.9217
More...
Q5CZC0
Fibrous sheath-interacting protein 2
ITCH
5867:5870
PPRY
ITCH,NEDD4
0.994
More...
Q5VT52
Regulation of nuclear pre-mRNA domain-containing protein 2
ITCH
1458:1461
PPRY
ITCH,NEDD4
0.5362
More...
Q6VAB6
Kinase suppressor of Ras 2
ITCH
486:489
PPRY
ITCH,NEDD4
0.9326
More...
Q86TB9
Protein PAT1 homolog 1
ITCH
221:224
PPRY
ITCH,NEDD4
0.9488
More...
Q8TC29
Enkurin
ITCH
24:27
PPRY
ITCH,NEDD4
0.9988
More...
Q8WUF5
RelA-associated inhibitor
ITCH
67:70
PPRY
ITCH,NEDD4
0.994
More...
Q8WWW0
Ras association domain-containing protein 5
ITCH
21:24
PPRY
ITCH,NEDD4
0.8918
More...
Q96NY7
Chloride intracellular channel protein 6
ITCH
553:556
PPRY
ITCH,NEDD4
0.9782
More...
Q96SN8
CDK5 regulatory subunit-associated protein 2
ITCH
1239:1242
PPRY
ITCH,NEDD4
0.9754
More...
Q96T58
Msx2-interacting protein
ITCH
771:774
PPRY
ITCH,NEDD4
0.7541
More...
Q99959
Plakophilin-2
ITCH
191:194
PPRY
ITCH,NEDD4
0.9964
More...
Q9H2D6
TRIO and F-actin-binding protein
ITCH
1029:1032
PPRY
ITCH,NEDD4
0.9563
More...
Q9NQL9
Doublesex- and mab-3-related transcription factor 3
ITCH
365:368
PPRY
ITCH,NEDD4
0.9917
More...
Q9NR12
PDZ and LIM domain protein 7
ITCH
101:104
PPRY
ITCH,NEDD4
0.9771
More...
Q9NU39
Forkhead box protein D4-like 1
ITCH
266:269
PPRY
ITCH,NEDD4
0.9298
More...
Q9NYQ8
Protocadherin Fat 2
ITCH
4240:4243
PPRY
ITCH,NEDD4
0.9922
More...
Q9UJV9
Probable ATP-dependent RNA helicase DDX41
ITCH
148:151
PPRY
ITCH,NEDD4
0.9995
More...
Q9ULH7
Myocardin-related transcription factor B
ITCH
871:874
PPRY
ITCH,NEDD4
0.999
More...
O15417
Trinucleotide repeat-containing gene 18 protein
ITCH
1079:1082
PPRY
ITCH,NEDD4
0.9345
More...
Q8WVE6
Transmembrane protein 171
ITCH
301:304
PPRY
ITCH,NEDD4
0.9994
More...
