DegronMD - P21860(ERBB3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E981D	TCGA-XF-A9T8	BLCA	TCGA	PPRY	ITCH	972:975	Mutation rewiring degron network	0.1667
p.R967K	SIDM00611	Kidney Carcinoma	GDSC	PPRY	ITCH	972:975	Mutation rewiring degron network	0.1944
p.R967K	SIDM00531	Pancreatic Carcinoma	GDSC	PPRY	ITCH	972:975	Mutation rewiring degron network	0.1944
p.R967K	SIDM01622	Breast Carcinoma	GDSC	PPRY	ITCH	972:975	Mutation rewiring degron network	0.1944
p.R967K	SIDM00959	Acute Myeloid Leukemia	GDSC	PPRY	ITCH	972:975	Mutation rewiring degron network	0.1944
p.R967K	CMK	haematopoietic and lymphoid tissue	COSMIC	PPRY	ITCH	972:975	Mutation rewiring degron network	0.1944
p.R967K	KMRC-1	kidney	COSMIC	PPRY	ITCH	972:975	Mutation rewiring degron network	0.1944
p.R967K	HuP-T4	pancreas	COSMIC	PPRY	ITCH	972:975	Mutation rewiring degron network	0.1944
p.E981Q	SIDM00358	Gastric Carcinoma	GDSC	PPRY	ITCH	972:975	Mutation rewiring degron network	0.1667
p.E981Q	ACH-000144	Gastric Cancer	CCLE	PPRY	ITCH	972:975	Mutation rewiring degron network	0.1667
p.E981Q	ACH-000976	Bile Duct Cancer	CCLE	PPRY	ITCH	972:975	Mutation rewiring degron network	0.1667
p.E981Q	RERF-GC-1B	stomach	COSMIC	PPRY	ITCH	972:975	Mutation rewiring degron network	0.1667
p.R974Q	SIDM00968	Ovarian Carcinoma	GDSC	PPRY	ITCH	972:975	Mutation altering degron motif	0.6218
p.R974Q	ACH-002140	Ovarian Cancer	CCLE	PPRY	ITCH	972:975	Mutation altering degron motif	0.6218
p.R974Q	Hey	ovary	COSMIC	PPRY	ITCH	972:975	Mutation altering degron motif	0.6218
p.L979V	NCI-H2110	lung	COSMIC	PPRY	ITCH	972:975	Mutation substituting flanking lysine	0.3333
p.R983C	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PPRY	ITCH	972:975	Mutation rewiring degron network	0.1111

Kaplan plot for ERBB3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ERBB3

UniProt ID: P21860

Entrez ID: 2065

Protein name: Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ERBB3 in