DegronMD

Uniprot ID: P21860

Source protein: Receptor tyrosine-protein kinase erbB-3

Source gene: ERBB3

Class: ITCH

Location: 972:975

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9993

ASA_SCORE: 71.675

COIL: 0.7138

CONS_SCORE: 0.4626

DSS_SCORE: 0.4331

HELIX: 0.0925

FCONS_SCORE: 1.2732

RIG_SCORE: 0.7698

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E981D	TCGA-XF-A9T8	BLCA	TCGA	PPRY	ITCH	0.1667
p.R967K	SIDM00611	Kidney Carcinoma	GDSC	PPRY	ITCH	0.1944
p.R967K	SIDM00531	Pancreatic Carcinoma	GDSC	PPRY	ITCH	0.1944
p.R967K	SIDM01622	Breast Carcinoma	GDSC	PPRY	ITCH	0.1944
p.R967K	SIDM00959	Acute Myeloid Leukemia	GDSC	PPRY	ITCH	0.1944
p.R967K	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PPRY	ITCH	0.1944
p.R967K	KMRC-1	kidney	COSMIC	PPRY	ITCH	0.1944
p.R967K	HuP-T4	pancreas	COSMIC	PPRY	ITCH	0.1944
p.E981Q	SIDM00358	Gastric Carcinoma	GDSC	PPRY	ITCH	0.1667
p.E981Q	ACH-000144	Gastric Cancer	CCLE	PPRY	ITCH	0.1667
p.E981Q	ACH-000976	Bile Duct Cancer	CCLE	PPRY	ITCH	0.1667
p.E981Q	RERF-GC-1B	stomach	COSMIC	PPRY	ITCH	0.1667
p.R974Q	SIDM00968	Ovarian Carcinoma	GDSC	PPRY	ITCH	0.6218
p.R974Q	ACH-002140	Ovarian Cancer	CCLE	PPRY	ITCH	0.6218
p.R974Q	Hey	ovary	COSMIC	PPRY	ITCH	0.6218
p.L979V	NCI-H2110	lung	COSMIC	PPRY	ITCH	0.3333
p.R983C	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPRY	ITCH	0.1111

Drug responses associated with ERBB3 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00214	COREAD\|large_intestine	p.V104M (No)	GDSC	AZD8931	0.068
SIDM00214	COREAD\|large_intestine	p.V104M (No)	GDSC	Sapitinib	17.668
SIDM00220	OV\|ovary	p.V104M (No)	GDSC	AZD8931	1.8147
SIDM00220	OV\|ovary	p.V104M (No)	GDSC	Sapitinib	23.919
SIDM01182	BLCA\|bladder	p.M91I (No)	GDSC	AZD8931	6.2868
SIDM01182	BLCA\|bladder	p.M91I (No)	GDSC	Sapitinib	55.205
SIDM00771	LUAD\|lung_NSCLC_adenocarcinoma	p.V104_R106delVVR (No)	GDSC	AZD8931	2.148
SIDM00771	LUAD\|lung_NSCLC_adenocarcinoma	p.V104_R106delVVR (No)	GDSC	Sapitinib	34.855
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.S410N (No)	GDSC	AZD8931	7.8602
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.S410N (No)	GDSC	Sapitinib	50.652
SIDM00240	CESC\|cervix	p.E1189K (No)	GDSC	AZD8931	13.3697
SIDM00240	CESC\|cervix	p.E1218Q (No)	GDSC	AZD8931	13.3697
SIDM00240	CESC\|cervix	p.Q1340H (No)	GDSC	AZD8931	13.3697
SIDM00578	NB\|neuroblastoma	p.R1202W (No)	GDSC	AZD8931	3.0635
SIDM00578	NB\|neuroblastoma	p.R1202W (No)	GDSC	Sapitinib	40.835
SIDM00190	SKCM\|melanoma	p.G325R (No)	GDSC	AZD8931	4.7202
SIDM00190	SKCM\|melanoma	p.G325R (No)	GDSC	Sapitinib	168.74
SIDM00325	ESCA\|oesophagus	p.V1003L (No)	GDSC	AZD8931	3.7891
SIDM00325	ESCA\|oesophagus	p.V1003L (No)	GDSC	Sapitinib	39.636
SIDM01031	ESCA\|oesophagus	p.D297Y (No)	GDSC	AZD8931	5.6602
SIDM01031	ESCA\|oesophagus	p.D297Y (No)	GDSC	Sapitinib	21
SIDM00358	STAD\|stomach	p.E981Q (Yes)	GDSC	AZD8931	4.0539
SIDM00358	STAD\|stomach	p.E981Q (Yes)	GDSC	Sapitinib	13.526
SIDM01029	ESCA\|oesophagus	p.R1202W (No)	GDSC	AZD8931	1.9365
SIDM01029	ESCA\|oesophagus	p.R1202W (No)	GDSC	Sapitinib	4.554
SIDM00572	STAD\|stomach	p.G1273R (No)	GDSC	AZD8931	1.266
SIDM00572	STAD\|stomach	p.G1273R (No)	GDSC	Sapitinib	3.1902
SIDM00688	DLBC\|B_cell_lymphoma	p.E1219K (No)	GDSC	AZD8931	8.1663
SIDM00688	DLBC\|B_cell_lymphoma	p.E1219K (No)	GDSC	Sapitinib	74.97
SIDM01086	ALL\|leukemia	p.Y1289H (No)	GDSC	AZD8931	5.7646
SIDM01086	ALL\|leukemia	p.Y1289H (No)	GDSC	Sapitinib	89.914
SIDM00315	GBM\|glioma	p.R490C (No)	GDSC	AZD8931	6.7806
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.E332K (No)	GDSC	AZD8931	4.7375
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.E332K (No)	GDSC	Sapitinib	52.536
SIDM00449	UNCLASSIFIED\|B_cell_leukemia	p.H591Y (No)	GDSC	AZD8931	4.2533
SIDM00151	OV\|ovary	p.K742E (No)	GDSC	AZD8931	12.467
SIDM00151	OV\|ovary	p.K742E (No)	GDSC	Sapitinib	1.2251
SIDM00499	PRAD\|prostate	p.R683Q (No)	GDSC	AZD8931	6.7703
SIDM00499	PRAD\|prostate	p.R683Q (No)	GDSC	Sapitinib	261.95
SIDM00145	ALL\|lymphoblastic_leukemia	p.R193* (No)	GDSC	AZD8931	10.8315
SIDM00145	ALL\|lymphoblastic_leukemia	p.R193* (No)	GDSC	Sapitinib	47.179
SIDM00145	ALL\|lymphoblastic_leukemia	p.R679* (No)	GDSC	AZD8931	10.8315
SIDM00145	ALL\|lymphoblastic_leukemia	p.R679* (No)	GDSC	Sapitinib	47.179
SIDM00959	LAML\|acute_myeloid_leukaemia	p.R967K (Yes)	GDSC	AZD8931	42.547
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.V1246A (No)	GDSC	AZD8931	12.2614
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.V1246A (No)	GDSC	Sapitinib	26.161
SIDM00683	PRAD\|prostate	p.K177N (No)	GDSC	AZD8931	3.3096
SIDM00683	PRAD\|prostate	p.K177N (No)	GDSC	Sapitinib	122.67
SIDM00957	COREAD\|large_intestine	p.Q1239H (No)	GDSC	AZD8931	16.4562
SIDM00957	COREAD\|large_intestine	p.Q1239H (No)	GDSC	Sapitinib	38.327
SIDM00334	UCEC\|endometrium	p.C186fs*20 (No)	GDSC	AZD8931	3.1237
SIDM00334	UCEC\|endometrium	p.C186fs*20 (No)	GDSC	Sapitinib	498.9
SIDM00956	ESCA\|oesophagus	p.G513D (No)	GDSC	AZD8931	18.9154
SIDM00956	ESCA\|oesophagus	p.G513D (No)	GDSC	Sapitinib	64.585
SIDM01162	KIRC\|kidney	p.R460M (No)	GDSC	AZD8931	3.8401
SIDM01048	MM\|lymphoid_neoplasm_other	p.G80E (No)	GDSC	AZD8931	10.9157
SIDM01048	MM\|lymphoid_neoplasm_other	p.G80E (No)	GDSC	Sapitinib	104.18
SIDM00142	UCEC\|endometrium	p.V119I (No)	GDSC	AZD8931	42.0975
SIDM00142	UCEC\|endometrium	p.V119I (No)	GDSC	Sapitinib	229.73
SIDM00980	STAD\|stomach	p.E1223A (No)	GDSC	AZD8931	3.8058
SIDM00980	STAD\|stomach	p.E1223A (No)	GDSC	Sapitinib	15.471
SIDM00126	SKCM\|melanoma	p.R55W (No)	GDSC	AZD8931	5.006
SIDM00145	ALL\|lymphoblastic_leukemia	p.N697fs*17 (No)	GDSC	AZD8931	10.8315
SIDM00145	ALL\|lymphoblastic_leukemia	p.N697fs*17 (No)	GDSC	Sapitinib	47.179
SIDM00312	MM\|myeloma	p.E479K (No)	GDSC	AZD8931	5.556
SIDM00312	MM\|myeloma	p.E479K (No)	GDSC	Sapitinib	41.587
SIDM00214	COREAD\|large_intestine	p.P262H (No)	GDSC	AZD8931	0.068
SIDM00214	COREAD\|large_intestine	p.P262H (No)	GDSC	Sapitinib	17.668
SIDM00320	LUAD\|lung_NSCLC_adenocarcinoma	p.E448* (No)	GDSC	AZD8931	3.6005
SIDM00320	LUAD\|lung_NSCLC_adenocarcinoma	p.E448* (No)	GDSC	Sapitinib	193.25
SIDM01090	COREAD\|large_intestine	p.A1302P (No)	GDSC	AZD8931	9.1674
SIDM01090	COREAD\|large_intestine	p.A1302P (No)	GDSC	Sapitinib	74.975
SIDM00498	COREAD\|large_intestine	p.I65M (No)	GDSC	AZD8931	7.1828
SIDM00498	COREAD\|large_intestine	p.I65M (No)	GDSC	Sapitinib	245.19
SIDM00151	OV\|ovary	p.H1304fs*7 (No)	GDSC	AZD8931	12.467
SIDM00151	OV\|ovary	p.H1304fs*7 (No)	GDSC	Sapitinib	1.2251
SIDM00946	ALL\|T_cell_leukemia	p.S413fs*3 (No)	GDSC	AZD8931	6.9416
SIDM00946	ALL\|T_cell_leukemia	p.S413fs*3 (No)	GDSC	Sapitinib	67.562
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.R1042C (No)	GDSC	AZD8931	12.1657
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.R1042C (No)	GDSC	Sapitinib	28.316
SIDM00791	LCML\|chronic_myeloid_leukaemia	p.R611W (No)	GDSC	AZD8931	5.708
SIDM00791	LCML\|chronic_myeloid_leukaemia	p.R611W (No)	GDSC	Sapitinib	136.18
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y888C (No)	GDSC	AZD8931	41.6356
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y888C (No)	GDSC	Sapitinib	33.612
SIDM00333	UCEC\|endometrium	p.W902* (No)	GDSC	AZD8931	1.2313
SIDM00333	UCEC\|endometrium	p.W902* (No)	GDSC	Sapitinib	35.28
SIDM00217	COREAD\|large_intestine	p.A232V (No)	GDSC	AZD8931	73.2569
SIDM00217	COREAD\|large_intestine	p.A232V (No)	GDSC	Sapitinib	38.257
SIDM00217	COREAD\|large_intestine	p.H374Y (No)	GDSC	AZD8931	73.2569
SIDM00217	COREAD\|large_intestine	p.H374Y (No)	GDSC	Sapitinib	38.257
SIDM00217	COREAD\|large_intestine	p.R683L (No)	GDSC	AZD8931	73.2569
SIDM00217	COREAD\|large_intestine	p.R683L (No)	GDSC	Sapitinib	38.257
SIDM00217	COREAD\|large_intestine	p.P1162L (No)	GDSC	AZD8931	73.2569
SIDM00217	COREAD\|large_intestine	p.P1162L (No)	GDSC	Sapitinib	38.257
SIDM00217	COREAD\|large_intestine	p.R1309H (No)	GDSC	AZD8931	73.2569
SIDM00217	COREAD\|large_intestine	p.R1309H (No)	GDSC	Sapitinib	38.257
SIDM00395	NB\|neuroblastoma	p.K998R (No)	GDSC	AZD8931	12.819
SIDM00395	NB\|neuroblastoma	p.K998R (No)	GDSC	Sapitinib	57.602
SIDM00898	BRCA\|breast	p.E952Q (No)	GDSC	AZD8931	0.6513
SIDM00898	BRCA\|breast	p.E952Q (No)	GDSC	Sapitinib	1.4636
SIDM00951	LAML\|acute_myeloid_leukaemia	p.E928fs*16 (No)	GDSC	AZD8931	1.3467
SIDM00951	LAML\|acute_myeloid_leukaemia	p.E928fs*16 (No)	GDSC	Sapitinib	1.3871
SIDM00596	UCEC\|endometrium	p.R475W (No)	GDSC	AZD8931	4.8684
SIDM00596	UCEC\|endometrium	p.R475W (No)	GDSC	Sapitinib	175.04
SIDM00596	UCEC\|endometrium	p.E1018D (No)	GDSC	AZD8931	4.8684
SIDM00596	UCEC\|endometrium	p.E1018D (No)	GDSC	Sapitinib	175.04
SIDM00282	COREAD\|large_intestine	p.E928G (No)	GDSC	AZD8931	7.086
SIDM00282	COREAD\|large_intestine	p.E928G (No)	GDSC	Sapitinib	1.9915
SIDM00338	LAML\|acute_myeloid_leukaemia	p.R1118Q (No)	GDSC	AZD8931	156.2839
SIDM00338	LAML\|acute_myeloid_leukaemia	p.R1118Q (No)	GDSC	Sapitinib	148.19
SIDM00660	COREAD\|large_intestine	p.W470* (No)	GDSC	AZD8931	13.5211
SIDM00660	COREAD\|large_intestine	p.W470* (No)	GDSC	Sapitinib	418.62
SIDM00660	COREAD\|large_intestine	p.A696S (No)	GDSC	AZD8931	13.5211
SIDM00660	COREAD\|large_intestine	p.A696S (No)	GDSC	Sapitinib	418.62
SIDM00660	COREAD\|large_intestine	p.R1309H (No)	GDSC	AZD8931	13.5211
SIDM00660	COREAD\|large_intestine	p.R1309H (No)	GDSC	Sapitinib	418.62
SIDM00783	COREAD\|large_intestine	p.Q261* (No)	GDSC	AZD8931	1.5223
SIDM00783	COREAD\|large_intestine	p.Q261* (No)	GDSC	Sapitinib	60.185
SIDM00783	COREAD\|large_intestine	p.G79D (No)	GDSC	AZD8931	1.5223
SIDM00783	COREAD\|large_intestine	p.G79D (No)	GDSC	Sapitinib	60.185
SIDM00969	OV\|ovary	p.A155V (No)	GDSC	AZD8931	3.0684
SIDM00969	OV\|ovary	p.A155V (No)	GDSC	Sapitinib	15.601
SIDM00703	UNCLASSIFIED\|lung_NSCLC_not_specified	p.L1038V (No)	GDSC	AZD8931	1.5156
SIDM00950	PAAD\|pancreas	p.I950T (No)	GDSC	AZD8931	1.2311
SIDM00950	PAAD\|pancreas	p.I950T (No)	GDSC	Sapitinib	20.163
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T1254A (No)	GDSC	AZD8931	7.1616
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T1254A (No)	GDSC	Sapitinib	68.954
SIDM00789	COREAD\|large_intestine	p.N126K (No)	GDSC	AZD8931	6.5336
SIDM00789	COREAD\|large_intestine	p.N126K (No)	GDSC	Sapitinib	33.178
SIDM00789	COREAD\|large_intestine	p.R667H (No)	GDSC	AZD8931	6.5336
SIDM00789	COREAD\|large_intestine	p.R667H (No)	GDSC	Sapitinib	33.178
SIDM00789	COREAD\|large_intestine	p.P1142H (No)	GDSC	AZD8931	6.5336
SIDM00789	COREAD\|large_intestine	p.P1142H (No)	GDSC	Sapitinib	33.178
SIDM01112	UNCLASSIFIED\|bone_other	p.E173Q (No)	GDSC	AZD8931	4.4658
SIDM01112	UNCLASSIFIED\|bone_other	p.E173Q (No)	GDSC	Sapitinib	140.32
SIDM00735	SCLC\|lung_small_cell_carcinoma	p.N369S (No)	GDSC	AZD8931	108.6274
SIDM00735	SCLC\|lung_small_cell_carcinoma	p.N369S (No)	GDSC	Sapitinib	60.135
SIDM00048	LUAD\|lung_NSCLC_adenocarcinoma	p.Y523C (No)	GDSC	AZD8931	0.0997
SIDM00542	GBM\|glioma	p.Q1239H (No)	GDSC	AZD8931	10.589
SIDM00542	GBM\|glioma	p.Q1239H (No)	GDSC	Sapitinib	111.81
SIDM01233	COREAD\|large_intestine	p.D857N (No)	GDSC	AZD8931	7.0126
SIDM01233	COREAD\|large_intestine	p.D857N (No)	GDSC	Sapitinib	8.4695
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.N487S (No)	GDSC	AZD8931	33.095
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.N487S (No)	GDSC	Sapitinib	34.317
SIDM00373	UCEC\|endometrium	p.G80V (No)	GDSC	AZD8931	0.3987
SIDM00373	UCEC\|endometrium	p.G80V (No)	GDSC	Sapitinib	11.79
SIDM01182	BLCA\|bladder	p.P689S (No)	GDSC	AZD8931	6.2868
SIDM01182	BLCA\|bladder	p.P689S (No)	GDSC	Sapitinib	55.205
SIDM00511	SCLC\|lung_small_cell_carcinoma	p.G1274V (No)	GDSC	AZD8931	53.1666
SIDM00511	SCLC\|lung_small_cell_carcinoma	p.G1274V (No)	GDSC	Sapitinib	79.295
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.T1024N (No)	GDSC	AZD8931	6.1737
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.T1024N (No)	GDSC	Sapitinib	237.38
SIDM00611	KIRC\|kidney	p.R967K (Yes)	GDSC	AZD8931	6.2575
SIDM00611	KIRC\|kidney	p.R967K (Yes)	GDSC	Sapitinib	50.2
SIDM01169	OV\|ovary	p.H1304fs*7 (No)	GDSC	AZD8931	1.0887
SIDM01169	OV\|ovary	p.H1304fs*7 (No)	GDSC	Sapitinib	15.94
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.R833K (No)	GDSC	AZD8931	12.395
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.R833K (No)	GDSC	Sapitinib	8.9908
SIDM00384	DLBC\|B_cell_lymphoma	p.P514L (No)	GDSC	Sapitinib	35.243
SIDM00384	DLBC\|B_cell_lymphoma	p.L812H (No)	GDSC	Sapitinib	35.243
SIDM00531	PAAD\|pancreas	p.R967K (Yes)	GDSC	AZD8931	1.3829
SIDM00531	PAAD\|pancreas	p.R967K (Yes)	GDSC	Sapitinib	65.375
SIDM00968	OV\|ovary	p.R974Q (Yes)	GDSC	AZD8931	6.5525
SIDM00968	OV\|ovary	p.R974Q (Yes)	GDSC	Sapitinib	172.96
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.Q1296* (No)	GDSC	AZD8931	6.3995
SIDM00860	HNSC\|head_and_neck	p.D297H (No)	GDSC	AZD8931	0.2907
SIDM00860	HNSC\|head_and_neck	p.D297H (No)	GDSC	Sapitinib	1.9535

All proteins holding degron of PPRY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6ND36	Protein FAM83G	ITCH	717:720	PPRY	ITCH,NEDD4	0.7033	More...
O00299	Chloride intracellular channel protein 1	ITCH	90:93	PPRY	ITCH,NEDD4	0.8886	More...
O15247	Chloride intracellular channel protein 2	ITCH	96:99	PPRY	ITCH,NEDD4	0.9319	More...
O43313	ATM interactor	ITCH	287:290	PPRY	ITCH,NEDD4	0.9841	More...
O43435	T-box transcription factor TBX1	ITCH	47:50	PPRY	ITCH,NEDD4	0.9424	More...
O75208	Ubiquinone biosynthesis protein COQ9, mitochondrial	ITCH	79:82	PPRY	ITCH,NEDD4	0.8635	More...
O95793	Double-stranded RNA-binding protein Staufen homolog 1	ITCH	113:116	PPRY	ITCH,NEDD4	0.9455	More...
P05198	Eukaryotic translation initiation factor 2 subunit 1	ITCH	232:235	PPRY	ITCH,NEDD4	0.6815	More...
P21860	Receptor tyrosine-protein kinase erbB-3	ITCH	972:975	PPRY	ITCH,NEDD4	0.9993	More...
P30876	DNA-directed RNA polymerase II subunit RPB2	ITCH	81:84	PPRY	ITCH,NEDD4	0.9176	More...
P53007	Tricarboxylate transport protein, mitochondrial	ITCH	61:64	PPRY	ITCH,NEDD4	0.7489	More...
P54753	Ephrin type-B receptor 3	ITCH	438:441	PPRY	ITCH,NEDD4	0.969	More...
Q09327	Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	ITCH	148:151	PPRY	ITCH,NEDD4	0.9144	More...
Q13825	Methylglutaconyl-CoA hydratase, mitochondrial	ITCH	333:336	PPRY	ITCH,NEDD4	0.5278	More...
Q14332	Frizzled-2	ITCH	189:192	PPRY	ITCH,NEDD4	0.5291	More...
Q14526	Hypermethylated in cancer 1 protein	ITCH	377:380	PPRY	ITCH,NEDD4	0.9217	More...
Q5CZC0	Fibrous sheath-interacting protein 2	ITCH	5867:5870	PPRY	ITCH,NEDD4	0.994	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	ITCH	1458:1461	PPRY	ITCH,NEDD4	0.5362	More...
Q6VAB6	Kinase suppressor of Ras 2	ITCH	486:489	PPRY	ITCH,NEDD4	0.9326	More...
Q86TB9	Protein PAT1 homolog 1	ITCH	221:224	PPRY	ITCH,NEDD4	0.9488	More...
Q8TC29	Enkurin	ITCH	24:27	PPRY	ITCH,NEDD4	0.9988	More...
Q8WUF5	RelA-associated inhibitor	ITCH	67:70	PPRY	ITCH,NEDD4	0.994	More...
Q8WWW0	Ras association domain-containing protein 5	ITCH	21:24	PPRY	ITCH,NEDD4	0.8918	More...
Q96NY7	Chloride intracellular channel protein 6	ITCH	553:556	PPRY	ITCH,NEDD4	0.9782	More...
Q96SN8	CDK5 regulatory subunit-associated protein 2	ITCH	1239:1242	PPRY	ITCH,NEDD4	0.9754	More...
Q96T58	Msx2-interacting protein	ITCH	771:774	PPRY	ITCH,NEDD4	0.7541	More...
Q99959	Plakophilin-2	ITCH	191:194	PPRY	ITCH,NEDD4	0.9964	More...
Q9H2D6	TRIO and F-actin-binding protein	ITCH	1029:1032	PPRY	ITCH,NEDD4	0.9563	More...
Q9NQL9	Doublesex- and mab-3-related transcription factor 3	ITCH	365:368	PPRY	ITCH,NEDD4	0.9917	More...
Q9NR12	PDZ and LIM domain protein 7	ITCH	101:104	PPRY	ITCH,NEDD4	0.9771	More...
Q9NU39	Forkhead box protein D4-like 1	ITCH	266:269	PPRY	ITCH,NEDD4	0.9298	More...
Q9NYQ8	Protocadherin Fat 2	ITCH	4240:4243	PPRY	ITCH,NEDD4	0.9922	More...
Q9UJV9	Probable ATP-dependent RNA helicase DDX41	ITCH	148:151	PPRY	ITCH,NEDD4	0.9995	More...
Q9ULH7	Myocardin-related transcription factor B	ITCH	871:874	PPRY	ITCH,NEDD4	0.999	More...
O15417	Trinucleotide repeat-containing gene 18 protein	ITCH	1079:1082	PPRY	ITCH,NEDD4	0.9345	More...
Q8WVE6	Transmembrane protein 171	ITCH	301:304	PPRY	ITCH,NEDD4	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPRY

Degron related mutations and impact score

Drug responses associated with ERBB3 mutations

All proteins holding degron of PPRY