DegronMD

Uniprot ID: P21860

Source protein: Receptor tyrosine-protein kinase erbB-3

Source gene: ERBB3

Class: ITCH

Location: 972:975

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9993

ASA_SCORE: 71.675

COIL: 0.7138

CONS_SCORE: 0.4626

DSS_SCORE: 0.4331

HELIX: 0.0925

FCONS_SCORE: 1.2732

RIG_SCORE: 0.7698

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R974Q	SIDM00968	Ovarian Carcinoma	GDSC	PPRY	ITCH	0.6218
p.R974Q	ACH-002140	Ovarian Cancer	CCLE	PPRY	ITCH	0.6218
p.R974Q	Hey	ovary	COSMIC	PPRY	ITCH	0.6218
p.L979V	NCI-H2110	lung	COSMIC	PPRY	ITCH	0.3333
p.R967K	SIDM00611	Kidney Carcinoma	GDSC	PPRY	ITCH	0.1944
p.R967K	SIDM00531	Pancreatic Carcinoma	GDSC	PPRY	ITCH	0.1944
p.R967K	SIDM01622	Breast Carcinoma	GDSC	PPRY	ITCH	0.1944
p.R967K	SIDM00959	Acute Myeloid Leukemia	GDSC	PPRY	ITCH	0.1944
p.R967K	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PPRY	ITCH	0.1944
p.R967K	KMRC-1	kidney	COSMIC	PPRY	ITCH	0.1944
p.R967K	HuP-T4	pancreas	COSMIC	PPRY	ITCH	0.1944
p.E981D	TCGA-XF-A9T8	BLCA	TCGA	PPRY	ITCH	0.1667
p.E981Q	SIDM00358	Gastric Carcinoma	GDSC	PPRY	ITCH	0.1667
p.E981Q	ACH-000144	Gastric Cancer	CCLE	PPRY	ITCH	0.1667
p.E981Q	ACH-000976	Bile Duct Cancer	CCLE	PPRY	ITCH	0.1667
p.E981Q	RERF-GC-1B	stomach	COSMIC	PPRY	ITCH	0.1667
p.R983C	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPRY	ITCH	0.1111

Showing 1 to 17 of 17 entries

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Drug responses associated with ERBB3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01086	ALL\|leukemia	p.Y1289H (No)	GDSC	AZD8931	5.7646
SIDM01086	ALL\|leukemia	p.Y1289H (No)	GDSC	Sapitinib	89.914
SIDM00145	ALL\|lymphoblastic_leukemia	p.R193* (No)	GDSC	AZD8931	10.8315
SIDM00145	ALL\|lymphoblastic_leukemia	p.R193* (No)	GDSC	Sapitinib	47.179
SIDM00145	ALL\|lymphoblastic_leukemia	p.R679* (No)	GDSC	AZD8931	10.8315
SIDM00145	ALL\|lymphoblastic_leukemia	p.R679* (No)	GDSC	Sapitinib	47.179
SIDM00145	ALL\|lymphoblastic_leukemia	p.N697fs*17 (No)	GDSC	AZD8931	10.8315
SIDM00145	ALL\|lymphoblastic_leukemia	p.N697fs*17 (No)	GDSC	Sapitinib	47.179
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.N487S (No)	GDSC	AZD8931	33.095
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.N487S (No)	GDSC	Sapitinib	34.317
SIDM00946	ALL\|T_cell_leukemia	p.S413fs*3 (No)	GDSC	AZD8931	6.9416
SIDM00946	ALL\|T_cell_leukemia	p.S413fs*3 (No)	GDSC	Sapitinib	67.562
SIDM01182	BLCA\|bladder	p.M91I (No)	GDSC	AZD8931	6.2868
SIDM01182	BLCA\|bladder	p.M91I (No)	GDSC	Sapitinib	55.205
SIDM01182	BLCA\|bladder	p.P689S (No)	GDSC	AZD8931	6.2868
SIDM01182	BLCA\|bladder	p.P689S (No)	GDSC	Sapitinib	55.205
SIDM00898	BRCA\|breast	p.E952Q (No)	GDSC	AZD8931	0.6513
SIDM00898	BRCA\|breast	p.E952Q (No)	GDSC	Sapitinib	1.4636
SIDM00240	CESC\|cervix	p.E1189K (No)	GDSC	AZD8931	13.3697
SIDM00240	CESC\|cervix	p.E1218Q (No)	GDSC	AZD8931	13.3697
SIDM00240	CESC\|cervix	p.Q1340H (No)	GDSC	AZD8931	13.3697
SIDM00214	COREAD\|large_intestine	p.V104M (No)	GDSC	AZD8931	0.068
SIDM00214	COREAD\|large_intestine	p.V104M (No)	GDSC	Sapitinib	17.668
SIDM00957	COREAD\|large_intestine	p.Q1239H (No)	GDSC	AZD8931	16.4562
SIDM00957	COREAD\|large_intestine	p.Q1239H (No)	GDSC	Sapitinib	38.327

Showing 1 to 25 of 167 entries

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All proteins holding degron of PPRY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43313	ATM interactor	ITCH	287:290	PPRY	ITCH,NEDD4	0.9841	More...
Q09327	Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	ITCH	148:151	PPRY	ITCH,NEDD4	0.9144	More...
Q96SN8	CDK5 regulatory subunit-associated protein 2	ITCH	1239:1242	PPRY	ITCH,NEDD4	0.9754	More...
O00299	Chloride intracellular channel protein 1	ITCH	90:93	PPRY	ITCH,NEDD4	0.8886	More...
O15247	Chloride intracellular channel protein 2	ITCH	96:99	PPRY	ITCH,NEDD4	0.9319	More...
Q96NY7	Chloride intracellular channel protein 6	ITCH	553:556	PPRY	ITCH,NEDD4	0.9782	More...
P30876	DNA-directed RNA polymerase II subunit RPB2	ITCH	81:84	PPRY	ITCH,NEDD4	0.9176	More...
O95793	Double-stranded RNA-binding protein Staufen homolog 1	ITCH	113:116	PPRY	ITCH,NEDD4	0.9455	More...
Q9NQL9	Doublesex- and mab-3-related transcription factor 3	ITCH	365:368	PPRY	ITCH,NEDD4	0.9917	More...
Q8TC29	Enkurin	ITCH	24:27	PPRY	ITCH,NEDD4	0.9988	More...
P54753	Ephrin type-B receptor 3	ITCH	438:441	PPRY	ITCH,NEDD4	0.969	More...
P05198	Eukaryotic translation initiation factor 2 subunit 1	ITCH	232:235	PPRY	ITCH,NEDD4	0.6815	More...
Q5CZC0	Fibrous sheath-interacting protein 2	ITCH	5867:5870	PPRY	ITCH,NEDD4	0.994	More...
Q9NU39	Forkhead box protein D4-like 1	ITCH	266:269	PPRY	ITCH,NEDD4	0.9298	More...
Q14332	Frizzled-2	ITCH	189:192	PPRY	ITCH,NEDD4	0.5291	More...
Q14526	Hypermethylated in cancer 1 protein	ITCH	377:380	PPRY	ITCH,NEDD4	0.9217	More...
Q6VAB6	Kinase suppressor of Ras 2	ITCH	486:489	PPRY	ITCH,NEDD4	0.9326	More...
Q13825	Methylglutaconyl-CoA hydratase, mitochondrial	ITCH	333:336	PPRY	ITCH,NEDD4	0.5278	More...
Q96T58	Msx2-interacting protein	ITCH	771:774	PPRY	ITCH,NEDD4	0.7541	More...
Q9ULH7	Myocardin-related transcription factor B	ITCH	871:874	PPRY	ITCH,NEDD4	0.999	More...
Q9NR12	PDZ and LIM domain protein 7	ITCH	101:104	PPRY	ITCH,NEDD4	0.9771	More...
Q99959	Plakophilin-2	ITCH	191:194	PPRY	ITCH,NEDD4	0.9964	More...
Q9UJV9	Probable ATP-dependent RNA helicase DDX41	ITCH	148:151	PPRY	ITCH,NEDD4	0.9995	More...
A6ND36	Protein FAM83G	ITCH	717:720	PPRY	ITCH,NEDD4	0.7033	More...
Q86TB9	Protein PAT1 homolog 1	ITCH	221:224	PPRY	ITCH,NEDD4	0.9488	More...

Showing 1 to 25 of 36 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPRY

Degron related mutations and impact score

Drug responses associated with ERBB3 mutations

All proteins holding degron of PPRY