DegronMD - Q99959(PKP2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S251C	TCGA-44-8117	LUAD	TCGA	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation blocking phosphorylation signal	0.6111
p.S251C	DO24028	LUAD	ICGC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation blocking phosphorylation signal	0.6111
p.R250G	TCGA-55-A4DG	LUAD	TCGA	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.1389
p.R250G	DO26337	LUAD	ICGC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.1389
p.H213Y	TCGA-61-2012	OV	TCGA	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.2222
p.H213Y	DO32536	OV	ICGC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.2222
p.R142K	TCGA-62-A46R	LUAD	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7237
p.R142K	DO45355	LUAD	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7237
p.R204L	TCGA-63-5128	LUSC	TCGA	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.3056
p.R204L	TCGA-63-5128	LUSC	TCGA	PPRY	ITCH	191:194	Mutation rewiring degron network	0.0556
p.R204L	DO27255	LUSC	ICGC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.3056
p.R204L	DO27255	LUSC	ICGC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.0556
p.R142S	TCGA-64-5781	LUAD	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7427
p.R142S	DO23740	LUAD	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7427
p.R142M	TCGA-64-5781	LUAD	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.8632
p.R142M	DO23740	LUAD	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.8632
p.R142M	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.8632
p.R142M	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.8632
p.R142M	ACH-000590	Lung Cancer	CCLE	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.8632
p.R142M	ACH-001137	Lung Cancer	CCLE	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.8632
p.R142M	NCI-H1993	lung	COSMIC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.8632
p.E157Q	TCGA-68-8251	LUSC	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1111
p.E157Q	DO26858	LUSC	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1111
p.R212H	TCGA-A6-2686	COAD	TCGA	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.25
p.R212H	TCGA-IB-7651	PAAD	TCGA	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.25
p.R212H	DO7828	COAD	ICGC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.25
p.R212H	DO46657	PAAD	ICGC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.25
p.R212H	SIDM02041	Colorectal Carcinoma	GDSC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.25
p.A187T	TCGA-AJ-A2QO	UCEC	TCGA	PPRY	ITCH	191:194	Mutation rewiring degron network	0.2222
p.A187T	DO233260	GACA	ICGC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.2222
p.A187T	DO42177	UCEC	ICGC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.2222
p.A187T	SIDM00220	Ovarian Carcinoma	GDSC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.2222
p.A187T	ACH-000962	Ovarian Cancer	CCLE	PPRY	ITCH	191:194	Mutation rewiring degron network	0.2222
p.A187T	ACH-001145	Ovarian Cancer	CCLE	PPRY	ITCH	191:194	Mutation rewiring degron network	0.2222
p.A187T	OC-314	ovary	COSMIC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.2222
p.A264T	TCGA-AP-A1DK	UCEC	TCGA	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.25
p.A264T	DO42033	UCEC	ICGC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.25
p.R185W	TCGA-B5-A1MR	UCEC	TCGA	PPRY	ITCH	191:194	Mutation rewiring degron network	0.1667
p.R185W	TCGA-F1-6874	STAD	TCGA	PPRY	ITCH	191:194	Mutation rewiring degron network	0.1667
p.R185W	DO38201	STAD	ICGC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.1667
p.R185W	DO41758	UCEC	ICGC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.1667
p.P192S	TCGA-BF-A5EO	SKCM	TCGA	PPRY	ITCH	191:194	Mutation altering degron motif	0.6752
p.P192S	DO219450	SKCM	ICGC	PPRY	ITCH	191:194	Mutation altering degron motif	0.6752
p.R158K	TCGA-BH-A0HF	BRCA	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.0833
p.R158K	DO1749	BRCA	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.0833
p.R158K	DO229346	LAML	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.0833
p.R158K	SIDM00437	Acute Myeloid Leukemia	GDSC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.0833
p.R158K	SIDM01151	Hepatocellular Carcinoma	GDSC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.0833
p.R158K	SIDM00487	Colorectal Carcinoma	GDSC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.0833
p.R158K	CCK-81	large intestine	COSMIC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.0833
p.R158K	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.0833
p.R158K	SNU-182	liver	COSMIC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.0833
p.T263M	TCGA-BR-4361	STAD	TCGA	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation blocking phosphorylation signal	0.7222
p.T263M	DO38887	STAD	ICGC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation blocking phosphorylation signal	0.7222
p.S132F	TCGA-CQ-A4C6	HNSC	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation blocking phosphorylation signal	0.5278
p.S132F	DO49047	HNSC	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation blocking phosphorylation signal	0.5278
p.S132F	ACH-000635	Ovarian Cancer	CCLE	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation blocking phosphorylation signal	0.5278
p.R388W	TCGA-D3-A8GI	SKCM	TCGA	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation rewiring degron network	0.1667
p.R388W	DO229456	SKCA	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation rewiring degron network	0.1667
p.R388W	DO50284	SKCM	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation rewiring degron network	0.1667
p.R390K	TCGA-D3-A8GL	SKCM	TCGA	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation rewiring degron network	0.2222
p.R390K	DO50287	SKCM	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation rewiring degron network	0.2222
p.R390K	Sarc9371	bone	COSMIC	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation rewiring degron network	0.2222
p.E137K	TCGA-D3-A8GM	SKCM	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.2222
p.E137K	DO50288	SKCM	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.2222
p.G269R	TCGA-DH-A7UR	LGG	TCGA	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.1111
p.G269R	DO51809	LGG	ICGC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.1111
p.G269R	DO34288	PACA	ICGC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.1111
p.R196C	TCGA-EB-A431	SKCM	TCGA	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.0833
p.R196C	TCGA-EB-A431	SKCM	TCGA	PPRY	ITCH	191:194	Mutation rewiring degron network	0.2778
p.R196C	DO37671	SKCM	ICGC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.0833
p.R196C	DO37671	SKCM	ICGC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.2778
p.R395C	TCGA-EE-A2MR	SKCM	TCGA	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.8301
p.R395C	TCGA-ER-A199	SKCM	TCGA	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.8301
p.R395C	TCGA-YG-AA3N	SKCM	TCGA	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.8301
p.R395C	DO222702	MELA	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.8301
p.R395C	DO37819	SKCM	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.8301
p.R395C	DO47395	SKCM	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.8301
p.R395C	DO51298	SKCM	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.8301
p.R204H	TCGA-EO-A22S	UCEC	TCGA	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.3056
p.R204H	TCGA-EO-A22S	UCEC	TCGA	PPRY	ITCH	191:194	Mutation rewiring degron network	0.0556
p.R204H	DO41590	UCEC	ICGC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.3056
p.R204H	DO41590	UCEC	ICGC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.0556
p.L394F	TCGA-FW-A3R5	SKCM	TCGA	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.587
p.L394F	DO37406	SKCM	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.587
p.E138K	TCGA-W3-AA1Q	SKCM	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.25
p.E138K	DO219487	SKCM	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.25
p.P144S	TCGA-W3-AA1V	SKCM	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.5641
p.P144S	DO51276	SKCM	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.5641
p.E149A	DO1156	BRCA	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.659
p.N254K	DO7214	CLLE	ICGC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.25
p.N254K	DO229015	LICA	ICGC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.25
p.R196H	DO233869	GACA	ICGC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.0833
p.R196H	DO233869	GACA	ICGC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.2778
p.R196H	ACH-001610	Brain Cancer	CCLE	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.0833
p.R196H	ACH-001610	Brain Cancer	CCLE	PPRY	ITCH	191:194	Mutation rewiring degron network	0.2778
p.G396D	DO228957	LICA	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation altering degron motif	0.6087
p.H218Q	DO229027	LICA	ICGC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.0833
p.S209R	DO229026	LICA	ICGC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation altering degron motif	0.7427
p.P191T	DO229034	LICA	ICGC	PPRY	ITCH	191:194	Mutation altering degron motif	0.7031
p.Q407K	DO229038	LICA	ICGC	LRGILKLLQ	DEG_APCC_DBOX_1	394:402	Mutation rewiring degron network	0.1944
p.T263K	DO229037	LICA	ICGC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation blocking phosphorylation signal	0.7222
p.L262V	DO44754	LICA	ICGC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.3056
p.R219K	DO222527	MELA	ICGC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.0556
p.G253D	DO222908	MELA	ICGC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.2222
p.R210M	DO232061	ORCA	ICGC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.3056
p.R219I	DO232761	PBCA	ICGC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.0556
p.S140T	SIDM01095	Rhabdomyosarcoma	GDSC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation blocking phosphorylation signal	0.75
p.S140T	ACH-000833	Sarcoma	CCLE	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation blocking phosphorylation signal	0.75
p.S140T	SJRH30	soft tissue	COSMIC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation blocking phosphorylation signal	0.75
p.V202A	SIDM00656	Burkitt's Lymphoma	GDSC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.25
p.V202A	SIDM00656	Burkitt's Lymphoma	GDSC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.1111
p.S151F	SIDM00281	Other Solid Cancers	GDSC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation blocking phosphorylation signal	0.7222
p.S151F	ACH-002100	Skin Cancer	CCLE	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation blocking phosphorylation signal	0.7222
p.S151F	DJM-1	skin	COSMIC	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation blocking phosphorylation signal	0.7222
p.A264V	SIDM00087	Plasma Cell Myeloma	GDSC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.25
p.A264V	SIDM00971	Breast Carcinoma	GDSC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.25
p.A264V	SIDM01133	Other Solid Cancers	GDSC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.25
p.A264V	SIDM00628	Breast Carcinoma	GDSC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.25
p.A264V	SIDM01686	Chronic Myelogenous Leukemia	GDSC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.25
p.R250L	SIDM00223	Small Cell Lung Carcinoma	GDSC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.1389
p.R250L	ACH-002144	Lung Cancer	CCLE	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.1389
p.R250L	IST-SL1	lung	COSMIC	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.1389
p.R196L	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.0833
p.R196L	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.2778
p.R196L	ACH-000669	Lung Cancer	CCLE	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.0833
p.R196L	ACH-000669	Lung Cancer	CCLE	PPRY	ITCH	191:194	Mutation rewiring degron network	0.2778
p.R196L	SW900	lung	COSMIC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.0833
p.R196L	SW900	lung	COSMIC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.2778
p.P192L	SIDM00783	Colorectal Carcinoma	GDSC	PPRY	ITCH	191:194	Mutation altering degron motif	0.7582
p.P192L	ACH-000971	Colon/Colorectal Cancer	CCLE	PPRY	ITCH	191:194	Mutation altering degron motif	0.7582
p.P192L	HCT-116	large intestine	COSMIC	PPRY	ITCH	191:194	Mutation altering degron motif	0.7582
p.L188I	SIDM00861	Ovarian Carcinoma	GDSC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.25
p.L188I	ACH-000906	Ovarian Cancer	CCLE	PPRY	ITCH	191:194	Mutation rewiring degron network	0.25
p.L188I	ES-2	ovary	COSMIC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.25
p.R185Q	SIDM01693	B-Lymphoblastic Leukemia	GDSC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.1667
p.R185Q	ACH-000032	Leukemia	CCLE	PPRY	ITCH	191:194	Mutation rewiring degron network	0.1667
p.R147S	ACH-000712	Lung Cancer	CCLE	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.6316
p.R147K	ACH-000712	Lung Cancer	CCLE	LRHPLRRLE	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.6126
p.G269E	ACH-001554	Eye Cancer	CCLE	EKENY	DEG_APCC_KENBOX_2	257:261	Mutation rewiring degron network	0.1111
p.V200M	ACH-002287	Colon/Colorectal Cancer	CCLE	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1944
p.V200M	ACH-002287	Colon/Colorectal Cancer	CCLE	PPRY	ITCH	191:194	Mutation rewiring degron network	0.1667
p.V200M	NCI-H630	large intestine	COSMIC	AGTTS	DEG_SPOP_SBC_1	205:209	Mutation rewiring degron network	0.1944
p.V200M	NCI-H630	large intestine	COSMIC	PPRY	ITCH	191:194	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PKP2

UniProt ID: Q99959

Entrez ID: 5318

Protein name: Plakophilin-2

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PKP2 in