DegronMD

Uniprot ID: Q99959

Source protein: Plakophilin-2

Source gene: PKP2

Class: DEG_APCC_DBOX_1

Location: 141:149

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9509

ASA_SCORE: 111.0111

COIL: 0.8124

CONS_SCORE: 0.3671

DSS_SCORE: 0.5868

HELIX: 0.0843

FCONS_SCORE: 0.8738

RIG_SCORE: 0.7053

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R142K	TCGA-62-A46R	LUAD	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	0.7237
p.R142K	DO45355	LUAD	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	0.7237
p.R142S	TCGA-64-5781	LUAD	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	0.7427
p.R142S	DO23740	LUAD	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	0.7427
p.R142M	TCGA-64-5781	LUAD	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	0.8632
p.R142M	DO23740	LUAD	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	0.8632
p.R142M	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	LRHPLRRLE	DEG_APCC_DBOX_1	0.8632
p.R142M	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	LRHPLRRLE	DEG_APCC_DBOX_1	0.8632
p.R142M	ACH-000590	Lung Cancer	CCLE	LRHPLRRLE	DEG_APCC_DBOX_1	0.8632
p.R142M	ACH-001137	Lung Cancer	CCLE	LRHPLRRLE	DEG_APCC_DBOX_1	0.8632
p.R142M	NCI-H1993	lung	COSMIC	LRHPLRRLE	DEG_APCC_DBOX_1	0.8632
p.E157Q	TCGA-68-8251	LUSC	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	0.1111
p.E157Q	DO26858	LUSC	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	0.1111
p.R158K	TCGA-BH-A0HF	BRCA	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	0.0833
p.R158K	DO1749	BRCA	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	0.0833
p.R158K	DO229346	LAML	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	0.0833
p.R158K	SIDM00437	Acute Myeloid Leukemia	GDSC	LRHPLRRLE	DEG_APCC_DBOX_1	0.0833
p.R158K	SIDM01151	Hepatocellular Carcinoma	GDSC	LRHPLRRLE	DEG_APCC_DBOX_1	0.0833
p.R158K	SIDM00487	Colorectal Carcinoma	GDSC	LRHPLRRLE	DEG_APCC_DBOX_1	0.0833
p.R158K	CCK-81	large_intestine	COSMIC	LRHPLRRLE	DEG_APCC_DBOX_1	0.0833
p.R158K	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	LRHPLRRLE	DEG_APCC_DBOX_1	0.0833
p.R158K	SNU-182	liver	COSMIC	LRHPLRRLE	DEG_APCC_DBOX_1	0.0833
p.S132F	TCGA-CQ-A4C6	HNSC	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	0.5278
p.S132F	DO49047	HNSC	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	0.5278
p.S132F	ACH-000635	Ovarian Cancer	CCLE	LRHPLRRLE	DEG_APCC_DBOX_1	0.5278
p.E137K	TCGA-D3-A8GM	SKCM	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	0.2222
p.E137K	DO50288	SKCM	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	0.2222
p.E138K	TCGA-W3-AA1Q	SKCM	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	0.25
p.E138K	DO219487	SKCM	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	0.25
p.P144S	TCGA-W3-AA1V	SKCM	TCGA	LRHPLRRLE	DEG_APCC_DBOX_1	0.5641
p.P144S	DO51276	SKCM	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	0.5641
p.E149A	DO1156	BRCA	ICGC	LRHPLRRLE	DEG_APCC_DBOX_1	0.659
p.S140T	SIDM01095	Rhabdomyosarcoma	GDSC	LRHPLRRLE	DEG_APCC_DBOX_1	0.75
p.S140T	ACH-000833	Sarcoma	CCLE	LRHPLRRLE	DEG_APCC_DBOX_1	0.75
p.S140T	SJRH30	soft_tissue	COSMIC	LRHPLRRLE	DEG_APCC_DBOX_1	0.75
p.S151F	SIDM00281	Other Solid Cancers	GDSC	LRHPLRRLE	DEG_APCC_DBOX_1	0.7222
p.S151F	ACH-002100	Skin Cancer	CCLE	LRHPLRRLE	DEG_APCC_DBOX_1	0.7222
p.S151F	DJM-1	skin	COSMIC	LRHPLRRLE	DEG_APCC_DBOX_1	0.7222
p.R147S	ACH-000712	Lung Cancer	CCLE	LRHPLRRLE	DEG_APCC_DBOX_1	0.6316
p.R147K	ACH-000712	Lung Cancer	CCLE	LRHPLRRLE	DEG_APCC_DBOX_1	0.6126

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRHPLRRLE

Degron related mutations and impact score

Drug responses associated with PKP2 mutations

All proteins holding degron of LRHPLRRLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99959	Plakophilin-2	DEG_APCC_DBOX_1	141:149	LRHPLRRLE	APC,CDC20,FZR1	0.9509	More...