DegronMD

Uniprot ID: Q99959

Source protein: Plakophilin-2

Source gene: PKP2

Class: DEG_SPOP_SBC_1

Location: 205:209

E3 ligase: SPOP

DEGRON score: 0.9955

ASA_SCORE: 62.78

COIL: 0.841

CONS_SCORE: 0.3433

DSS_SCORE: 0.4779

HELIX: 0.0748

FCONS_SCORE: 0.9013

RIG_SCORE: 0.6619

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H213Y	TCGA-61-2012	OV	TCGA	AGTTS	DEG_SPOP_SBC_1	0.2222
p.H213Y	DO32536	OV	ICGC	AGTTS	DEG_SPOP_SBC_1	0.2222
p.R204L	TCGA-63-5128	LUSC	TCGA	AGTTS	DEG_SPOP_SBC_1	0.3056
p.R204L	DO27255	LUSC	ICGC	AGTTS	DEG_SPOP_SBC_1	0.3056
p.R212H	TCGA-A6-2686	COAD	TCGA	AGTTS	DEG_SPOP_SBC_1	0.25
p.R212H	TCGA-IB-7651	PAAD	TCGA	AGTTS	DEG_SPOP_SBC_1	0.25
p.R212H	DO7828	COAD	ICGC	AGTTS	DEG_SPOP_SBC_1	0.25
p.R212H	DO46657	PAAD	ICGC	AGTTS	DEG_SPOP_SBC_1	0.25
p.R212H	SIDM02041	Colorectal Carcinoma	GDSC	AGTTS	DEG_SPOP_SBC_1	0.25
p.R196C	TCGA-EB-A431	SKCM	TCGA	AGTTS	DEG_SPOP_SBC_1	0.0833
p.R196C	DO37671	SKCM	ICGC	AGTTS	DEG_SPOP_SBC_1	0.0833
p.R204H	TCGA-EO-A22S	UCEC	TCGA	AGTTS	DEG_SPOP_SBC_1	0.3056
p.R204H	DO41590	UCEC	ICGC	AGTTS	DEG_SPOP_SBC_1	0.3056
p.R196H	DO233869	GACA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.0833
p.R196H	ACH-001610	Brain Cancer	CCLE	AGTTS	DEG_SPOP_SBC_1	0.0833
p.H218Q	DO229027	LICA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.0833
p.S209R	DO229026	LICA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.7427
p.R219K	DO222527	MELA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.0556
p.R210M	DO232061	ORCA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.3056
p.R219I	DO232761	PBCA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.0556
p.V202A	SIDM00656	Burkitt's Lymphoma	GDSC	AGTTS	DEG_SPOP_SBC_1	0.25
p.R196L	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	AGTTS	DEG_SPOP_SBC_1	0.0833
p.R196L	ACH-000669	Lung Cancer	CCLE	AGTTS	DEG_SPOP_SBC_1	0.0833
p.R196L	SW900	lung	COSMIC	AGTTS	DEG_SPOP_SBC_1	0.0833
p.V200M	ACH-002287	Colon/Colorectal Cancer	CCLE	AGTTS	DEG_SPOP_SBC_1	0.1944
p.V200M	NCI-H630	large_intestine	COSMIC	AGTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	974:978	AGTTS	SPOP	0.9922	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	DEG_SPOP_SBC_1	215:219	AGTTS	SPOP	0.9938	More...
Q8TAQ2	SWI/SNF complex subunit SMARCC2	DEG_SPOP_SBC_1	741:745	AGTTS	SPOP	0.9966	More...
Q92750	Transcription initiation factor TFIID subunit 4B	DEG_SPOP_SBC_1	491:495	AGTTS	SPOP	0.9528	More...
Q96JP5	E3 ubiquitin-protein ligase ZFP91	DEG_SPOP_SBC_1	42:46	AGTTS	SPOP	0.9924	More...
Q99959	Plakophilin-2	DEG_SPOP_SBC_1	205:209	AGTTS	SPOP	0.9955	More...
Q9H228	Sphingosine 1-phosphate receptor 5	DEG_SPOP_SBC_1	233:237	AGTTS	SPOP	0.7632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons