DegronMD

Uniprot ID: Q92750

Source protein: Transcription initiation factor TFIID subunit 4B

Source gene: TAF4B

Class: DEG_SPOP_SBC_1

Location: 491:495

E3 ligase: SPOP

DEGRON score: 0.9528

ASA_SCORE: 69.84

COIL: 0.8912

CONS_SCORE: 0.3958

DSS_SCORE: 0.4066

HELIX: 0.0216

FCONS_SCORE: 1.0069

RIG_SCORE: 0.6617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P486L	TCGA-AJ-A3EL	UCEC	TCGA	AGTTS	DEG_SPOP_SBC_1	0.1944
p.P486L	TCGA-B5-A3FC	UCEC	TCGA	AGTTS	DEG_SPOP_SBC_1	0.1944
p.P486L	DO41542	UCEC	ICGC	AGTTS	DEG_SPOP_SBC_1	0.1944
p.P486L	DO41871	UCEC	ICGC	AGTTS	DEG_SPOP_SBC_1	0.1944
p.V488D	TCGA-D9-A6EC	SKCM	TCGA	AGTTS	DEG_SPOP_SBC_1	0.25
p.V488D	DO50291	SKCM	ICGC	AGTTS	DEG_SPOP_SBC_1	0.25
p.P486H	TCGA-IB-7651	PAAD	TCGA	AGTTS	DEG_SPOP_SBC_1	0.1944
p.P486H	DO46657	PAAD	ICGC	AGTTS	DEG_SPOP_SBC_1	0.1944
p.A491S	DO229037	LICA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.7588
p.T493N	DO229253	THCA	ICGC	AGTTS	DEG_SPOP_SBC_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	974:978	AGTTS	SPOP	0.9922	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	DEG_SPOP_SBC_1	215:219	AGTTS	SPOP	0.9938	More...
Q8TAQ2	SWI/SNF complex subunit SMARCC2	DEG_SPOP_SBC_1	741:745	AGTTS	SPOP	0.9966	More...
Q92750	Transcription initiation factor TFIID subunit 4B	DEG_SPOP_SBC_1	491:495	AGTTS	SPOP	0.9528	More...
Q96JP5	E3 ubiquitin-protein ligase ZFP91	DEG_SPOP_SBC_1	42:46	AGTTS	SPOP	0.9924	More...
Q99959	Plakophilin-2	DEG_SPOP_SBC_1	205:209	AGTTS	SPOP	0.9955	More...
Q9H228	Sphingosine 1-phosphate receptor 5	DEG_SPOP_SBC_1	233:237	AGTTS	SPOP	0.7632	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons