DegronMD - Q92750(TAF4B)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R137I	TCGA-05-4424	LUAD	TCGA	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.3056
p.R137I	DO23672	LUAD	ICGC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.3056
p.Q598R	TCGA-5M-AAT6	COAD	TCGA	IKENV	DEG_APCC_KENBOX_2	602:606	Mutation rewiring degron network	0.2222
p.P486L	TCGA-AJ-A3EL	UCEC	TCGA	AGTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1944
p.P486L	TCGA-B5-A3FC	UCEC	TCGA	AGTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1944
p.P486L	DO41542	UCEC	ICGC	AGTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1944
p.P486L	DO41871	UCEC	ICGC	AGTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1944
p.I602T	TCGA-BH-A8FY	BRCA	TCGA	IKENV	DEG_APCC_KENBOX_2	602:606	Mutation altering degron motif	0.5966
p.V488D	TCGA-D9-A6EC	SKCM	TCGA	AGTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.25
p.V488D	DO50291	SKCM	ICGC	AGTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.25
p.P486H	TCGA-IB-7651	PAAD	TCGA	AGTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1944
p.P486H	DO46657	PAAD	ICGC	AGTTS	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1944
p.I607T	DO219613	BRCA	ICGC	IKENV	DEG_APCC_KENBOX_2	602:606	Mutation rewiring degron network	0.3056
p.Q603R	DO223703	COAD	ICGC	IKENV	DEG_APCC_KENBOX_2	602:606	Mutation altering degron motif	0.7329
p.A599T	DO228756	GACA	ICGC	IKENV	DEG_APCC_KENBOX_2	602:606	Mutation blocking ubiquitination signal	0.6944
p.S596L	DO14156	HNSC	ICGC	IKENV	DEG_APCC_KENBOX_2	602:606	Mutation rewiring degron network	0.1667
p.R616L	DO229028	LICA	ICGC	IKENV	DEG_APCC_KENBOX_2	602:606	Mutation rewiring degron network	0.0556
p.V150L	DO229038	LICA	ICGC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1111
p.A491S	DO229037	LICA	ICGC	AGTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.7588
p.T612K	DO50859	LIRI	ICGC	IKENV	DEG_APCC_KENBOX_2	602:606	Mutation rewiring degron network	0.1667
p.T493N	DO229253	THCA	ICGC	AGTTS	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.7055
p.P148T	DO229539	UTCA	ICGC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.1667
p.A152T	SIDM01090	Colorectal Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.A152T	SIDM00969	Ovarian Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.A152T	SIDM00319	Melanoma	GDSC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.A152T	SIDM00971	Breast Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.A152T	SIDM00844	Burkitt's Lymphoma	GDSC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.A152T	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.A152V	SIDM01090	Colorectal Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.A152V	SIDM00969	Ovarian Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.A152V	SIDM00319	Melanoma	GDSC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.A152V	SIDM00971	Breast Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.A152V	SIDM00844	Burkitt's Lymphoma	GDSC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.A152V	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.0556
p.S142R	SIDM00498	Colorectal Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7427
p.S142R	ACH-000970	Colon/Colorectal Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7427
p.S142R	SNU-C5	large intestine	COSMIC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation altering degron motif	0.7427
p.I144M	SIDM00537	Colorectal Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2778
p.I144M	ACH-001345	Colon/Colorectal Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2778
p.I144M	GP5d	large intestine	COSMIC	AETTS	DEG_SPOP_SBC_1	138:142	Mutation rewiring degron network	0.2778

Kaplan plot for TAF4B in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAF4B

UniProt ID: Q92750

Entrez ID: 6875

Protein name: Transcription initiation factor TFIID subunit 4B (Transcription initiation factor TFIID 105 kDa subunit) (TAF(II)105) (TAFII-105) (TAFII105)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TAF4B in