DegronMD

Uniprot ID: Q92750

Source protein: Transcription initiation factor TFIID subunit 4B

Source gene: TAF4B

Class: DEG_APCC_KENBOX_2

Location: 602:606

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9209

ASA_SCORE: 98.66

COIL: 0.773

CONS_SCORE: 0.3939

DSS_SCORE: 0.4672

HELIX: 0.1276

FCONS_SCORE: 0.8376

RIG_SCORE: 0.7645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q598R	TCGA-5M-AAT6	COAD	TCGA	IKENV	DEG_APCC_KENBOX_2	0.2222
p.I602T	TCGA-BH-A8FY	BRCA	TCGA	IKENV	DEG_APCC_KENBOX_2	0.5966
p.I607T	DO219613	BRCA	ICGC	IKENV	DEG_APCC_KENBOX_2	0.3056
p.Q603R	DO223703	COAD	ICGC	IKENV	DEG_APCC_KENBOX_2	0.7329
p.A599T	DO228756	GACA	ICGC	IKENV	DEG_APCC_KENBOX_2	0.6944
p.S596L	DO14156	HNSC	ICGC	IKENV	DEG_APCC_KENBOX_2	0.1667
p.R616L	DO229028	LICA	ICGC	IKENV	DEG_APCC_KENBOX_2	0.0556
p.T612K	DO50859	LIRI	ICGC	IKENV	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92750	Transcription initiation factor TFIID subunit 4B	DEG_APCC_KENBOX_2	602:606	IKENV	APC,CDC20,FZR1	0.9209	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons