DegronMD

Uniprot ID: Q92750

Source protein: Transcription initiation factor TFIID subunit 4B

Source gene: TAF4B

Class: DEG_SPOP_SBC_1

Location: 138:142

E3 ligase: SPOP

DEGRON score: 0.9872

ASA_SCORE: 100.26

COIL: 0.9414

CONS_SCORE: 0.3795

DSS_SCORE: 0.5747

HELIX: 0.0318

FCONS_SCORE: 1.0024

RIG_SCORE: 0.7288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R137I	TCGA-05-4424	LUAD	TCGA	AETTS	DEG_SPOP_SBC_1	0.3056
p.R137I	DO23672	LUAD	ICGC	AETTS	DEG_SPOP_SBC_1	0.3056
p.V150L	DO229038	LICA	ICGC	AETTS	DEG_SPOP_SBC_1	0.1111
p.P148T	DO229539	UTCA	ICGC	AETTS	DEG_SPOP_SBC_1	0.1667
p.A152T	SIDM01090	Colorectal Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.0556
p.A152T	SIDM00969	Ovarian Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.0556
p.A152T	SIDM00319	Melanoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.0556
p.A152T	SIDM00971	Breast Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.0556
p.A152T	SIDM00844	Burkitt's Lymphoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.0556
p.A152T	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.0556
p.A152V	SIDM01090	Colorectal Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.0556
p.A152V	SIDM00969	Ovarian Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.0556
p.A152V	SIDM00319	Melanoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.0556
p.A152V	SIDM00971	Breast Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.0556
p.A152V	SIDM00844	Burkitt's Lymphoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.0556
p.A152V	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.0556
p.S142R	SIDM00498	Colorectal Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.7427
p.S142R	ACH-000970	Colon/Colorectal Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	0.7427
p.S142R	SNU-C5	large_intestine	COSMIC	AETTS	DEG_SPOP_SBC_1	0.7427
p.I144M	SIDM00537	Colorectal Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.2778
p.I144M	ACH-001345	Colon/Colorectal Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	0.2778
p.I144M	GP5d	large_intestine	COSMIC	AETTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PIF2	Synaptonemal complex central element protein 2	DEG_SPOP_SBC_1	199:203	AETTS	SPOP	0.8896	More...
Q8NG31	Kinetochore scaffold 1	DEG_SPOP_SBC_1	1656:1660	AETTS	SPOP	0.9488	More...
Q92750	Transcription initiation factor TFIID subunit 4B	DEG_SPOP_SBC_1	138:142	AETTS	SPOP	0.9872	More...
Q96PE2	Rho guanine nucleotide exchange factor 17	DEG_SPOP_SBC_1	1677:1681	AETTS	SPOP	0.9496	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons