DegronMD - Q6PIF2(SYCE2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V195A	TCGA-AX-A06F	UCEC	TCGA	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2222
p.V195A	DO41752	UCEC	ICGC	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2222
p.V198M	TCGA-CG-5726	STAD	TCGA	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.3056
p.V198M	DO38483	STAD	ICGC	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.3056
p.D192E	DO228931	LICA	ICGC	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1389
p.P190H	DO229029	LICA	ICGC	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0833
p.Q211R	SIDM00041	Gastric Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1111
p.Q211R	ACH-002306	Gastric Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1111
p.Q211R	STS-0421	soft tissue	COSMIC	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1111
p.P191Q	SIDM00852	Glioma	GDSC	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1111
p.P191Q	ACH-000389	Brain Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1111
p.P191Q	H4	central nervous system	COSMIC	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1111
p.V193M	SIDM00150	Colorectal Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1667
p.V193M	ACH-000969	Colon/Colorectal Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1667
p.V193M	KM12	large intestine	COSMIC	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1667
p.N213K	ACH-000791	Lung Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0556

Kaplan plot for SYCE2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYCE2

UniProt ID: Q6PIF2

Entrez ID: 256126

Protein name: Synaptonemal complex central element protein 2 (Central element synaptonemal complex protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYCE2 in