DegronMD

Uniprot ID: Q6PIF2

Source protein: Synaptonemal complex central element protein 2

Source gene: SYCE2

Class: DEG_SPOP_SBC_1

Location: 199:203

E3 ligase: SPOP

DEGRON score: 0.8896

ASA_SCORE: 72.64

COIL: 0.6128

CONS_SCORE: 0.2395

DSS_SCORE: 0.6113

HELIX: 0.1192

FCONS_SCORE: 1.0634

RIG_SCORE: 0.6849

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V195A	TCGA-AX-A06F	UCEC	TCGA	AETTS	DEG_SPOP_SBC_1	0.2222
p.V195A	DO41752	UCEC	ICGC	AETTS	DEG_SPOP_SBC_1	0.2222
p.V198M	TCGA-CG-5726	STAD	TCGA	AETTS	DEG_SPOP_SBC_1	0.3056
p.V198M	DO38483	STAD	ICGC	AETTS	DEG_SPOP_SBC_1	0.3056
p.D192E	DO228931	LICA	ICGC	AETTS	DEG_SPOP_SBC_1	0.1389
p.P190H	DO229029	LICA	ICGC	AETTS	DEG_SPOP_SBC_1	0.0833
p.Q211R	SIDM00041	Gastric Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.1111
p.Q211R	ACH-002306	Gastric Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	0.1111
p.Q211R	STS-0421	soft_tissue	COSMIC	AETTS	DEG_SPOP_SBC_1	0.1111
p.P191Q	SIDM00852	Glioma	GDSC	AETTS	DEG_SPOP_SBC_1	0.1111
p.P191Q	ACH-000389	Brain Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	0.1111
p.P191Q	H4	central_nervous_system	COSMIC	AETTS	DEG_SPOP_SBC_1	0.1111
p.V193M	SIDM00150	Colorectal Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.1667
p.V193M	ACH-000969	Colon/Colorectal Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	0.1667
p.V193M	KM12	large_intestine	COSMIC	AETTS	DEG_SPOP_SBC_1	0.1667
p.N213K	ACH-000791	Lung Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PIF2	Synaptonemal complex central element protein 2	DEG_SPOP_SBC_1	199:203	AETTS	SPOP	0.8896	More...
Q8NG31	Kinetochore scaffold 1	DEG_SPOP_SBC_1	1656:1660	AETTS	SPOP	0.9488	More...
Q92750	Transcription initiation factor TFIID subunit 4B	DEG_SPOP_SBC_1	138:142	AETTS	SPOP	0.9872	More...
Q96PE2	Rho guanine nucleotide exchange factor 17	DEG_SPOP_SBC_1	1677:1681	AETTS	SPOP	0.9496	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons