DegronMD - Q8NG31(KNL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1022I	SIDM00698	Small Cell Lung Carcinoma	GDSC	VICTPTEE	DEG_SCF_FBW7_2	1014:1021	Mutation rewiring degron network	0.3056
p.S1022I	NCI-H146	lung	COSMIC	VICTPTEE	DEG_SCF_FBW7_2	1014:1021	Mutation rewiring degron network	0.3056
p.E217K	SIDM01199	Hepatocellular Carcinoma	GDSC	LKLHTE	LIG_APCC_ABBA_1	212:217	Mutation altering degron motif	0.7022
p.E217K	SIDM00383	Gastric Carcinoma	GDSC	LKLHTE	LIG_APCC_ABBA_1	212:217	Mutation altering degron motif	0.7022
p.E217K	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	LKLHTE	LIG_APCC_ABBA_1	212:217	Mutation altering degron motif	0.7022
p.E217K	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	LKLHTE	LIG_APCC_ABBA_1	212:217	Mutation altering degron motif	0.7022
p.E217K	SIDM01450	Gastric Carcinoma	GDSC	LKLHTE	LIG_APCC_ABBA_1	212:217	Mutation altering degron motif	0.7022
p.E217K	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	LKLHTE	LIG_APCC_ABBA_1	212:217	Mutation altering degron motif	0.7022
p.P274L	SIDM00496	Thyroid Gland Carcinoma	GDSC	NFEIPIYSKEP	CBL_PTK	264:274	Mutation altering degron motif	0.7582
p.P274L	HTC-C3	thyroid	COSMIC	NFEIPIYSKEP	CBL_PTK	264:274	Mutation altering degron motif	0.7582
p.Q611R	SIDM00553	Acute Myeloid Leukemia	GDSC	PESTS	DEG_SPOP_SBC_1	621:625	Mutation rewiring degron network	0.0556
p.Q611R	SIDM00333	Endometrial Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	621:625	Mutation rewiring degron network	0.0556
p.Q611R	SIDM01372	Pancreatic Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	621:625	Mutation rewiring degron network	0.0556
p.R1006K	SIDM00571	Pancreatic Carcinoma	GDSC	VICTPTEE	DEG_SCF_FBW7_2	1014:1021	Mutation rewiring degron network	0.1111
p.R1006K	KP-3	pancreas	COSMIC	VICTPTEE	DEG_SCF_FBW7_2	1014:1021	Mutation rewiring degron network	0.1111
p.M550T	SIDM00457	Plasma Cell Myeloma	GDSC	PTPEKE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1389
p.M550T	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	PTPEKE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1389
p.M550T	OPM-2	haematopoietic and lymphoid tissue	COSMIC	PTPEKE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1389
p.M550T	TE-5	oesophagus	COSMIC	PTPEKE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1389
p.P1743L	SIDM00282	Colorectal Carcinoma	GDSC	LPVYPD	LIG_APCC_ABBA_1	1742:1747	Mutation altering degron motif	0.6471
p.P1743L	CW-2	large intestine	COSMIC	LPVYPD	LIG_APCC_ABBA_1	1742:1747	Mutation altering degron motif	0.6471
p.I269V	SIDM00971	Breast Carcinoma	GDSC	NFEIPIYSKEP	CBL_PTK	264:274	Mutation altering degron motif	0.5965
p.I269V	SIDM00032	Bladder Carcinoma	GDSC	NFEIPIYSKEP	CBL_PTK	264:274	Mutation altering degron motif	0.5965
p.I269V	SIDM00807	Bladder Carcinoma	GDSC	NFEIPIYSKEP	CBL_PTK	264:274	Mutation altering degron motif	0.5965
p.I269V	SIDM00793	Burkitt's Lymphoma	GDSC	NFEIPIYSKEP	CBL_PTK	264:274	Mutation altering degron motif	0.5965
p.I269V	SIDM00863	Burkitt's Lymphoma	GDSC	NFEIPIYSKEP	CBL_PTK	264:274	Mutation altering degron motif	0.5965
p.I269V	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	NFEIPIYSKEP	CBL_PTK	264:274	Mutation altering degron motif	0.5965
p.K1670R	SIDM00971	Breast Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	1656:1660	Mutation substituting flanking lysine	0.1667
p.K1670R	SIDM00032	Bladder Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	1656:1660	Mutation substituting flanking lysine	0.1667
p.K1670R	SIDM00807	Bladder Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	1656:1660	Mutation substituting flanking lysine	0.1667
p.K1670R	SIDM00793	Burkitt's Lymphoma	GDSC	AETTS	DEG_SPOP_SBC_1	1656:1660	Mutation substituting flanking lysine	0.1667
p.K1670R	SIDM00863	Burkitt's Lymphoma	GDSC	AETTS	DEG_SPOP_SBC_1	1656:1660	Mutation substituting flanking lysine	0.1667
p.K1670R	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	1656:1660	Mutation substituting flanking lysine	0.1667
p.C253Y	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DKENF	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.1111
p.C253Y	NCI-H1155	lung	COSMIC	DKENF	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.1111
p.S1008N	SIDM00493	Other Solid Cancers	GDSC	VICTPTEE	DEG_SCF_FBW7_2	1014:1021	Mutation blocking phosphorylation signal	0.6111
p.N618S	SIDM00050	Chondrosarcoma	GDSC	PESTS	DEG_SPOP_SBC_1	621:625	Mutation rewiring degron network	0.25
p.N618S	SIDM00105	Ovarian Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	621:625	Mutation rewiring degron network	0.25
p.N618S	SIDM00093	Ovarian Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	621:625	Mutation rewiring degron network	0.25
p.N618S	OVCAR-3	ovary	COSMIC	PESTS	DEG_SPOP_SBC_1	621:625	Mutation rewiring degron network	0.25
p.N618S	CHSA0108	bone	COSMIC	PESTS	DEG_SPOP_SBC_1	621:625	Mutation rewiring degron network	0.25
p.K262N	SIDM01019	Acute Myeloid Leukemia	GDSC	DKENF	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.6918
p.K262N	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	DKENF	DEG_APCC_KENBOX_2	261:265	Mutation altering degron motif	0.6918
p.P30L	SIDM00179	Melanoma	GDSC	PRSPLQDLR	DEG_APCC_DBOX_1	30:38	Mutation altering degron motif	0.6471
p.P257L	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	DKENF	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.2222
p.P257L	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	NFEIPIYSKEP	CBL_PTK	264:274	Mutation rewiring degron network	0.1389
p.P257L	ABC-1	lung	COSMIC	DKENF	DEG_APCC_KENBOX_2	261:265	Mutation rewiring degron network	0.2222
p.P257L	ABC-1	lung	COSMIC	NFEIPIYSKEP	CBL_PTK	264:274	Mutation rewiring degron network	0.1389
p.D897E	SIDM00863	Burkitt's Lymphoma	GDSC	KTIVFSE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation rewiring degron network	0.1944
p.T1665S	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	1656:1660	Mutation rewiring degron network	0.1944
p.T1665S	NCI-H1755	lung	COSMIC	AETTS	DEG_SPOP_SBC_1	1656:1660	Mutation rewiring degron network	0.1944
p.R22W	SIDM00667	Other Sarcomas	GDSC	PRSPLQDLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.1111
p.S1039N	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPLEE	DEG_SCF_FBW7_2	1041:1046	Mutation blocking phosphorylation signal	0.7222
p.S1039N	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	LTPLEE	DEG_SCF_FBW7_2	1041:1046	Mutation blocking phosphorylation signal	0.7222
p.T1659A	SIDM01608	Endometrial Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	1656:1660	Mutation altering degron motif	0.7139
p.L1034P	SIDM01560	Rhabdomyosarcoma	GDSC	LTPLEE	DEG_SCF_FBW7_2	1041:1046	Mutation rewiring degron network	0.1389
p.V1035I	SIDM01343	Gastric Carcinoma	GDSC	LTPLEE	DEG_SCF_FBW7_2	1041:1046	Mutation rewiring degron network	0.1667
p.P1717L	CW-2	large intestine	COSMIC	DSGIGS	DEG_SCF_TRCP1_1	1719:1724	Mutation rewiring degron network	0.2778
p.S902F	KYSE-220	oesophagus	COSMIC	KTIVFSE	LIG_APCC_ABBAyCdc20_2	886:892	Mutation substituting flanking lysine	0.1667
p.S1013N	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	VICTPTEE	DEG_SCF_FBW7_2	1014:1021	Mutation blocking phosphorylation signal	0.75
p.H541Y	ST486	haematopoietic and lymphoid tissue	COSMIC	PTPEKE	DEG_SCF_FBW7_2	538:543	Mutation altering degron motif	0.7229
p.E1745A	RKO	large intestine	COSMIC	LPVYPD	LIG_APCC_ABBA_1	1742:1747	Mutation altering degron motif	0.7701
p.N41D	PF-382	haematopoietic and lymphoid tissue	COSMIC	PRSPLQDLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.25
p.C227Y	NCI-H1155	lung	COSMIC	LKLHTE	LIG_APCC_ABBA_1	212:217	Mutation rewiring degron network	0.0556
p.N1525D	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	LKENI	DEG_APCC_KENBOX_2	1533:1537	Mutation rewiring degron network	0.1111
p.R1741T	DU-145	prostate	COSMIC	LPVYPD	LIG_APCC_ABBA_1	1742:1747	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KNL1

UniProt ID: Q8NG31

Entrez ID: 57082

Protein name: Kinetochore scaffold 1 (ALL1-fused gene from chromosome 15q14 protein) (AF15q14) (Bub-linking kinetochore protein) (Blinkin) (Cancer susceptibility candidate gene 5 protein) (Cancer/testis antigen 29) (CT29) (Kinetochore-null protein 1) (Protein CASC5) (Protein D40/AF15q14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KNL1 in