DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NFEIPIYSKEP
Uniprot ID:
Q8NG31
Source protein:
Kinetochore scaffold 1
Source gene:
KNL1
Class:
CBL_PTK
Location:
264:274
E3 ligase:
CBL
DEGRON score:
0.962
ASA_SCORE:
98.5636
COIL:
0.8617
CONS_SCORE:
0.433
DSS_SCORE:
0.5311
HELIX:
0.0354
FCONS_SCORE:
1.1402
RIG_SCORE:
0.743
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P274L
SIDM00496
Thyroid Gland Carcinoma
GDSC
NFEIPIYSKEP
CBL_PTK
0.7582
p.P274L
HTC-C3
thyroid
COSMIC
NFEIPIYSKEP
CBL_PTK
0.7582
p.I269V
SIDM00971
Breast Carcinoma
GDSC
NFEIPIYSKEP
CBL_PTK
0.5965
p.I269V
SIDM00032
Bladder Carcinoma
GDSC
NFEIPIYSKEP
CBL_PTK
0.5965
p.I269V
SIDM00807
Bladder Carcinoma
GDSC
NFEIPIYSKEP
CBL_PTK
0.5965
p.I269V
SIDM00793
Burkitt's Lymphoma
GDSC
NFEIPIYSKEP
CBL_PTK
0.5965
p.I269V
SIDM00863
Burkitt's Lymphoma
GDSC
NFEIPIYSKEP
CBL_PTK
0.5965
p.I269V
SIDM01710
Squamous Cell Lung Carcinoma
GDSC
NFEIPIYSKEP
CBL_PTK
0.5965
p.P257L
SIDM00494
Non-Small Cell Lung Carcinoma
GDSC
NFEIPIYSKEP
CBL_PTK
0.1389
p.P257L
ABC-1
lung
COSMIC
NFEIPIYSKEP
CBL_PTK
0.1389
Drug responses associated with KNL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NFEIPIYSKEP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NG31
Kinetochore scaffold 1
CBL_PTK
264:274
NFEIPIYSKEP
CBL
0.962
More...
