DegronMD

Uniprot ID: Q8NG31

Source protein: Kinetochore scaffold 1

Source gene: KNL1

Class: DEG_SCF_FBW7_2

Location: 1041:1046

E3 ligase: FBXW7

DEGRON score: 0.7368

ASA_SCORE: 86.8333

COIL: 0.6018

CONS_SCORE: 0.2704

DSS_SCORE: 0.5335

HELIX: 0.281

FCONS_SCORE: 0.8785

RIG_SCORE: 0.7538

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1039N	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPLEE	DEG_SCF_FBW7_2	0.7222
p.S1039N	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	LTPLEE	DEG_SCF_FBW7_2	0.7222
p.L1034P	SIDM01560	Rhabdomyosarcoma	GDSC	LTPLEE	DEG_SCF_FBW7_2	0.1389
p.V1035I	SIDM01343	Gastric Carcinoma	GDSC	LTPLEE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NG31	Kinetochore scaffold 1	DEG_SCF_FBW7_2	1041:1046	LTPLEE	FBXW7	0.7368	More...
Q9Y2B5	VPS9 domain-containing protein 1	DEG_SCF_FBW7_2	146:151	LTPLEE	FBXW7	0.9915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons