DegronMD - Q9Y2B5(VPS9D1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A137T	TCGA-2G-AAGF	TGCT	TCGA	LTPLEE	DEG_SCF_FBW7_2	146:151	Mutation rewiring degron network	0.0833
p.A137T	TCGA-CK-4951	COAD	TCGA	LTPLEE	DEG_SCF_FBW7_2	146:151	Mutation rewiring degron network	0.0833
p.A137T	DO10582	COAD	ICGC	LTPLEE	DEG_SCF_FBW7_2	146:151	Mutation rewiring degron network	0.0833
p.L149P	TCGA-56-7580	LUSC	TCGA	LTPLEE	DEG_SCF_FBW7_2	146:151	Mutation altering degron motif	0.6471
p.L149P	DO27675	LUSC	ICGC	LTPLEE	DEG_SCF_FBW7_2	146:151	Mutation altering degron motif	0.6471
p.E138Q	DO1094	BRCA	ICGC	LTPLEE	DEG_SCF_FBW7_2	146:151	Mutation rewiring degron network	0.1111
p.S141T	DO234343	ESAD	ICGC	LTPLEE	DEG_SCF_FBW7_2	146:151	Mutation rewiring degron network	0.1944
p.S153F	DO222837	MELA	ICGC	LTPLEE	DEG_SCF_FBW7_2	146:151	Mutation rewiring degron network	0.2778
p.A161V	SIDM00216	Colorectal Carcinoma	GDSC	LTPLEE	DEG_SCF_FBW7_2	146:151	Mutation rewiring degron network	0.0556
p.A161V	ACH-000989	Colon/Colorectal Cancer	CCLE	LTPLEE	DEG_SCF_FBW7_2	146:151	Mutation rewiring degron network	0.0556
p.A161V	SNU-175	large intestine	COSMIC	LTPLEE	DEG_SCF_FBW7_2	146:151	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons