DegronMD

Uniprot ID: Q9Y2B5

Source protein: VPS9 domain-containing protein 1

Source gene: VPS9D1

Class: DEG_SCF_FBW7_2

Location: 146:151

E3 ligase: FBXW7

DEGRON score: 0.9915

ASA_SCORE: 74.2333

COIL: 0.4508

CONS_SCORE: 0.6701

DSS_SCORE: 0.4646

HELIX: 0.5357

FCONS_SCORE: 1.2652

RIG_SCORE: 0.7575

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A137T	TCGA-2G-AAGF	TGCT	TCGA	LTPLEE	DEG_SCF_FBW7_2	0.0833
p.A137T	TCGA-CK-4951	COAD	TCGA	LTPLEE	DEG_SCF_FBW7_2	0.0833
p.A137T	DO10582	COAD	ICGC	LTPLEE	DEG_SCF_FBW7_2	0.0833
p.L149P	TCGA-56-7580	LUSC	TCGA	LTPLEE	DEG_SCF_FBW7_2	0.6471
p.L149P	DO27675	LUSC	ICGC	LTPLEE	DEG_SCF_FBW7_2	0.6471
p.E138Q	DO1094	BRCA	ICGC	LTPLEE	DEG_SCF_FBW7_2	0.1111
p.S141T	DO234343	ESAD	ICGC	LTPLEE	DEG_SCF_FBW7_2	0.1944
p.S153F	DO222837	MELA	ICGC	LTPLEE	DEG_SCF_FBW7_2	0.2778
p.A161V	SIDM00216	Colorectal Carcinoma	GDSC	LTPLEE	DEG_SCF_FBW7_2	0.0556
p.A161V	ACH-000989	Colon/Colorectal Cancer	CCLE	LTPLEE	DEG_SCF_FBW7_2	0.0556
p.A161V	SNU-175	large_intestine	COSMIC	LTPLEE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NG31	Kinetochore scaffold 1	DEG_SCF_FBW7_2	1041:1046	LTPLEE	FBXW7	0.7368	More...
Q9Y2B5	VPS9 domain-containing protein 1	DEG_SCF_FBW7_2	146:151	LTPLEE	FBXW7	0.9915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons