DegronMD

Uniprot ID: Q8NG31

Source protein: Kinetochore scaffold 1

Source gene: KNL1

Class: DEG_APCC_KENBOX_2

Location: 1533:1537

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9726

ASA_SCORE: 108.08

COIL: 0.6274

CONS_SCORE: 0.3569

DSS_SCORE: 0.2364

HELIX: 0.3386

FCONS_SCORE: 1.3339

RIG_SCORE: 0.8096

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1525D	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	LKENI	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02224	Centromere-associated protein E	DEG_APCC_KENBOX_2	1073:1077	LKENI	APC,CDC20,FZR1	0.6832	More...
Q8NG31	Kinetochore scaffold 1	DEG_APCC_KENBOX_2	1533:1537	LKENI	APC,CDC20,FZR1	0.9726	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons