DegronMD - Q02224(CENPE)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1363F	TCGA-14-0817	GBM	TCGA	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.1944
p.V1363F	TCGA-14-0817	GBM	TCGA	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation rewiring degron network	0.0833
p.V1363F	DO13653	GBM	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.1944
p.V1363F	DO13653	GBM	ICGC	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation rewiring degron network	0.0833
p.I1198K	TCGA-30-1853	OV	TCGA	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation rewiring degron network	0.25
p.I1198K	DO28002	OV	ICGC	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation rewiring degron network	0.25
p.Q147E	TCGA-34-2600	LUSC	TCGA	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.0556
p.Q147E	DO27081	LUSC	ICGC	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.0556
p.S1384G	TCGA-44-3918	LUAD	TCGA	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation rewiring degron network	0.2222
p.S1384G	DO23732	LUAD	ICGC	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation rewiring degron network	0.2222
p.I1063M	TCGA-50-5066	LUAD	TCGA	LKENI	DEG_APCC_KENBOX_2	1073:1077	Mutation rewiring degron network	0.0556
p.I1063M	DO25040	LUAD	ICGC	LKENI	DEG_APCC_KENBOX_2	1073:1077	Mutation rewiring degron network	0.0556
p.V129L	TCGA-78-7148	LUAD	TCGA	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.25
p.V129L	DO26112	LUAD	ICGC	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.25
p.S1346A	TCGA-AG-3892	READ	TCGA	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.2222
p.S1346A	DO36394	READ	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.2222
p.S1197Y	TCGA-AX-A0J0	UCEC	TCGA	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation rewiring degron network	0.2222
p.S1197Y	DO41133	UCEC	ICGC	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation rewiring degron network	0.2222
p.S1346Y	TCGA-AX-A1CE	UCEC	TCGA	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.2222
p.S1346Y	TCGA-EO-A3AV	UCEC	TCGA	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.2222
p.S1346Y	DO42280	UCEC	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.2222
p.S1346Y	DO52412	UCEC	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.2222
p.A969V	TCGA-B5-A0JY	UCEC	TCGA	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation altering degron motif	0.5825
p.A969V	DO43041	UCEC	ICGC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation altering degron motif	0.5825
p.L126I	TCGA-B5-A11N	UCEC	TCGA	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1667
p.L126I	DO41458	UCEC	ICGC	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.1667
p.S1346F	TCGA-B5-A3FC	UCEC	TCGA	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.2222
p.S1346F	DO41871	UCEC	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.2222
p.K984I	TCGA-BC-A10Z	LIHC	TCGA	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation substituting flanking lysine	0.1667
p.K984I	DO23043	LIHC	ICGC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation substituting flanking lysine	0.1667
p.E137K	TCGA-BH-A0B6	BRCA	TCGA	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation altering degron motif	0.7022
p.E137K	DO2641	BRCA	ICGC	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation altering degron motif	0.7022
p.L1205V	TCGA-BH-A0HP	BRCA	TCGA	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation altering degron motif	0.6765
p.L1205V	DO1755	BRCA	ICGC	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation altering degron motif	0.6765
p.R128C	TCGA-BR-8680	STAD	TCGA	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.2222
p.R128C	DO47769	STAD	ICGC	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.2222
p.T1356M	TCGA-BS-A0UV	UCEC	TCGA	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation altering degron motif	0.6312
p.T1356M	DO42793	UCEC	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation altering degron motif	0.6312
p.E1374K	TCGA-CN-4735	HNSC	TCGA	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation altering degron motif	0.591
p.E1374K	DO14172	HNSC	ICGC	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation altering degron motif	0.591
p.H976L	TCGA-CN-6021	HNSC	TCGA	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation rewiring degron network	0.2778
p.H976L	DO15847	HNSC	ICGC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation rewiring degron network	0.2778
p.R967Q	TCGA-D1-A17B	UCEC	TCGA	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation altering degron motif	0.7329
p.R967Q	TCGA-D8-A1JK	BRCA	TCGA	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation altering degron motif	0.7329
p.R967Q	DO3880	BRCA	ICGC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation altering degron motif	0.7329
p.R967Q	DO231742	LINC	ICGC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation altering degron motif	0.7329
p.R967Q	DO43017	UCEC	ICGC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation altering degron motif	0.7329
p.R967Q	SIDM00419	Ewing's Sarcoma	GDSC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation altering degron motif	0.7329
p.F1212Y	TCGA-DW-7838	KIRP	TCGA	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation rewiring degron network	0.25
p.F1212Y	DO20815	KIRP	ICGC	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation rewiring degron network	0.25
p.T1348I	TCGA-EE-A2A1	SKCM	TCGA	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.2778
p.T1348I	DO38045	SKCM	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.2778
p.T1348I	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.2778
p.T1348I	NCI-H810	lung	COSMIC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.2778
p.E1213K	TCGA-FR-A8YC	SKCM	TCGA	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation rewiring degron network	0.2222
p.E1213K	DO50301	SKCM	ICGC	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation rewiring degron network	0.2222
p.R1202K	TCGA-GN-A263	SKCM	TCGA	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation altering degron motif	0.7237
p.R1202K	DO37766	SKCM	ICGC	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation altering degron motif	0.7237
p.D122A	TCGA-R5-A7ZI	STAD	TCGA	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.0556
p.D122A	DO222342	STAD	ICGC	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.0556
p.D122H	TCGA-S5-A6DX	BLCA	TCGA	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.0556
p.D122H	DO51903	BLCA	ICGC	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.0556
p.E1078K	DO48408	BLCA	ICGC	LKENI	DEG_APCC_KENBOX_2	1073:1077	Mutation rewiring degron network	0.3056
p.N968T	DO5745	BRCA	ICGC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation altering degron motif	0.5944
p.R1216K	DO50437	ESAD	ICGC	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation rewiring degron network	0.1389
p.L970R	DO234274	ESAD	ICGC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation altering degron motif	0.8428
p.L970I	DO234274	ESAD	ICGC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation altering degron motif	0.7174
p.N1353D	DO233290	GACA	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation altering degron motif	0.5821
p.D1352E	DO229055	LICA	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation altering degron motif	0.5647
p.L1368M	DO229057	LICA	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.0556
p.L1368M	DO229057	LICA	ICGC	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation rewiring degron network	0.2222
p.L1361S	DO220886	MELA	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.25
p.L1361P	DO220886	MELA	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.25
p.L1361F	DO220886	MELA	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.25
p.R128H	DO51169	PAEN	ICGC	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.2222
p.I960V	DO232761	PBCA	ICGC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation rewiring degron network	0.1667
p.K1206T	SIDM00973	Melanoma	GDSC	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation altering degron motif	0.6195
p.K1206T	WM793B	skin	COSMIC	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation altering degron motif	0.6195
p.N957H	SIDM00227	Neuroblastoma	GDSC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation rewiring degron network	0.0833
p.N957H	GI-ME-N	autonomic ganglia	COSMIC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation rewiring degron network	0.0833
p.T1080A	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	LKENI	DEG_APCC_KENBOX_2	1073:1077	Mutation rewiring degron network	0.25
p.T1080A	NCI-H1792	lung	COSMIC	LKENI	DEG_APCC_KENBOX_2	1073:1077	Mutation rewiring degron network	0.25
p.H1365L	SIDM00650	Small Cell Lung Carcinoma	GDSC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.1389
p.H1365L	SIDM00650	Small Cell Lung Carcinoma	GDSC	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation rewiring degron network	0.1389
p.H1365L	SIDM00875	Breast Carcinoma	GDSC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.1389
p.H1365L	SIDM00875	Breast Carcinoma	GDSC	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation rewiring degron network	0.1389
p.H1365L	SIDM00068	Colorectal Carcinoma	GDSC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.1389
p.H1365L	SIDM00068	Colorectal Carcinoma	GDSC	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation rewiring degron network	0.1389
p.H1365L	SIDM01681	Non-Cancerous	GDSC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.1389
p.H1365L	SIDM01681	Non-Cancerous	GDSC	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation rewiring degron network	0.1389
p.H1365L	SIDM01525	Acute Myeloid Leukemia	GDSC	ERDNLKTIK	DEG_APCC_DBOX_1	1350:1358	Mutation rewiring degron network	0.1389
p.H1365L	SIDM01525	Acute Myeloid Leukemia	GDSC	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation rewiring degron network	0.1389
p.R967L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation altering degron motif	0.8428
p.R967L	ACH-000951	Lung Cancer	CCLE	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation altering degron motif	0.8428
p.R967L	NCI-H2342	lung	COSMIC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation altering degron motif	0.8428
p.I1077V	SIDM00217	Colorectal Carcinoma	GDSC	LKENI	DEG_APCC_KENBOX_2	1073:1077	Mutation altering degron motif	0.5965
p.I1077V	SNU-1040	large intestine	COSMIC	LKENI	DEG_APCC_KENBOX_2	1073:1077	Mutation altering degron motif	0.5965
p.N957S	SIDM00217	Colorectal Carcinoma	GDSC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation rewiring degron network	0.0833
p.N957S	SNU-1040	large intestine	COSMIC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation rewiring degron network	0.0833
p.D141Y	SIDM01611	Endometrial Carcinoma	GDSC	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.2222
p.D141Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	MEIYNE	LIG_APCC_ABBA_1	132:137	Mutation rewiring degron network	0.2222
p.I1198T	SIDM00016	Neuroblastoma	GDSC	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation rewiring degron network	0.25
p.I1198T	EMC-BAC-1	lung	COSMIC	ERKVLKELQ	DEG_APCC_DBOX_1	1201:1209	Mutation rewiring degron network	0.25
p.E964Q	ACH-000530	Lung Cancer	CCLE	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation rewiring degron network	0.2778
p.E964Q	DMS-114	lung	COSMIC	LRNALESLK	DEG_APCC_DBOX_1	966:974	Mutation rewiring degron network	0.2778
p.A1390S	ACH-000803	Lung Cancer	CCLE	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation rewiring degron network	0.0556
p.A1390S	COLO-668	lung	COSMIC	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation rewiring degron network	0.0556
p.V1378M	ACH-000960	Leukemia	CCLE	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation altering degron motif	0.7208
p.V1378M	REH	haematopoietic and lymphoid tissue	COSMIC	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation altering degron motif	0.7208
p.N1372D	ACH-000997	Colon/Colorectal Cancer	CCLE	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation altering degron motif	0.6932
p.N1372D	HCT-15	large intestine	COSMIC	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation altering degron motif	0.6932
p.K1085N	ACH-002800	Unknown	CCLE	LKENI	DEG_APCC_KENBOX_2	1073:1077	Mutation rewiring degron network	0.1111
p.S1379N	8-MG-BA	central nervous system	COSMIC	IRETLAKIQ	DEG_APCC_DBOX_1	1372:1380	Mutation altering degron motif	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CENPE

UniProt ID: Q02224

Entrez ID: 1062

Protein name: Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin-7) (Kinesin-related protein CENPE)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CENPE in