DegronMD

Uniprot ID: Q02224

Source protein: Centromere-associated protein E

Source gene: CENPE

Class: DEG_APCC_DBOX_1

Location: 1350:1358

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5508

ASA_SCORE: 99.7111

COIL: 0.085

CONS_SCORE: 0.3122

DSS_SCORE: 0.378

HELIX: 0.9158

FCONS_SCORE: 1.0708

RIG_SCORE: 0.7639

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1363F	TCGA-14-0817	GBM	TCGA	ERDNLKTIK	DEG_APCC_DBOX_1	0.1944
p.V1363F	DO13653	GBM	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	0.1944
p.S1346A	TCGA-AG-3892	READ	TCGA	ERDNLKTIK	DEG_APCC_DBOX_1	0.2222
p.S1346A	DO36394	READ	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	0.2222
p.S1346Y	TCGA-AX-A1CE	UCEC	TCGA	ERDNLKTIK	DEG_APCC_DBOX_1	0.2222
p.S1346Y	TCGA-EO-A3AV	UCEC	TCGA	ERDNLKTIK	DEG_APCC_DBOX_1	0.2222
p.S1346Y	DO42280	UCEC	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	0.2222
p.S1346Y	DO52412	UCEC	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	0.2222
p.S1346F	TCGA-B5-A3FC	UCEC	TCGA	ERDNLKTIK	DEG_APCC_DBOX_1	0.2222
p.S1346F	DO41871	UCEC	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	0.2222
p.T1356M	TCGA-BS-A0UV	UCEC	TCGA	ERDNLKTIK	DEG_APCC_DBOX_1	0.6312
p.T1356M	DO42793	UCEC	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	0.6312
p.T1348I	TCGA-EE-A2A1	SKCM	TCGA	ERDNLKTIK	DEG_APCC_DBOX_1	0.2778
p.T1348I	DO38045	SKCM	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	0.2778
p.T1348I	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ERDNLKTIK	DEG_APCC_DBOX_1	0.2778
p.T1348I	NCI-H810	lung	COSMIC	ERDNLKTIK	DEG_APCC_DBOX_1	0.2778
p.N1353D	DO233290	GACA	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	0.5821
p.D1352E	DO229055	LICA	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	0.5647
p.L1368M	DO229057	LICA	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	0.0556
p.L1361S	DO220886	MELA	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	0.25
p.L1361P	DO220886	MELA	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	0.25
p.L1361F	DO220886	MELA	ICGC	ERDNLKTIK	DEG_APCC_DBOX_1	0.25
p.H1365L	SIDM00650	Small Cell Lung Carcinoma	GDSC	ERDNLKTIK	DEG_APCC_DBOX_1	0.1389
p.H1365L	SIDM00875	Breast Carcinoma	GDSC	ERDNLKTIK	DEG_APCC_DBOX_1	0.1389
p.H1365L	SIDM00068	Colorectal Carcinoma	GDSC	ERDNLKTIK	DEG_APCC_DBOX_1	0.1389
p.H1365L	SIDM01681	Non-Cancerous	GDSC	ERDNLKTIK	DEG_APCC_DBOX_1	0.1389
p.H1365L	SIDM01525	Acute Myeloid Leukemia	GDSC	ERDNLKTIK	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERDNLKTIK

Degron related mutations and impact score

Drug responses associated with CENPE mutations

All proteins holding degron of ERDNLKTIK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02224	Centromere-associated protein E	DEG_APCC_DBOX_1	1350:1358	ERDNLKTIK	APC,CDC20,FZR1	0.5508	More...