DegronMD

Uniprot ID: Q02224

Source protein: Centromere-associated protein E

Source gene: CENPE

Class: DEG_APCC_DBOX_1

Location: 1201:1209

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.834

ASA_SCORE: 103.3444

COIL: 0.0203

CONS_SCORE: 0.3286

DSS_SCORE: 0.316

HELIX: 0.9802

FCONS_SCORE: 1.1524

RIG_SCORE: 0.8153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1198K	TCGA-30-1853	OV	TCGA	ERKVLKELQ	DEG_APCC_DBOX_1	0.25
p.I1198K	DO28002	OV	ICGC	ERKVLKELQ	DEG_APCC_DBOX_1	0.25
p.S1197Y	TCGA-AX-A0J0	UCEC	TCGA	ERKVLKELQ	DEG_APCC_DBOX_1	0.2222
p.S1197Y	DO41133	UCEC	ICGC	ERKVLKELQ	DEG_APCC_DBOX_1	0.2222
p.L1205V	TCGA-BH-A0HP	BRCA	TCGA	ERKVLKELQ	DEG_APCC_DBOX_1	0.6765
p.L1205V	DO1755	BRCA	ICGC	ERKVLKELQ	DEG_APCC_DBOX_1	0.6765
p.F1212Y	TCGA-DW-7838	KIRP	TCGA	ERKVLKELQ	DEG_APCC_DBOX_1	0.25
p.F1212Y	DO20815	KIRP	ICGC	ERKVLKELQ	DEG_APCC_DBOX_1	0.25
p.E1213K	TCGA-FR-A8YC	SKCM	TCGA	ERKVLKELQ	DEG_APCC_DBOX_1	0.2222
p.E1213K	DO50301	SKCM	ICGC	ERKVLKELQ	DEG_APCC_DBOX_1	0.2222
p.R1202K	TCGA-GN-A263	SKCM	TCGA	ERKVLKELQ	DEG_APCC_DBOX_1	0.7237
p.R1202K	DO37766	SKCM	ICGC	ERKVLKELQ	DEG_APCC_DBOX_1	0.7237
p.R1216K	DO50437	ESAD	ICGC	ERKVLKELQ	DEG_APCC_DBOX_1	0.1389
p.K1206T	SIDM00973	Melanoma	GDSC	ERKVLKELQ	DEG_APCC_DBOX_1	0.6195
p.K1206T	WM793B	skin	COSMIC	ERKVLKELQ	DEG_APCC_DBOX_1	0.6195
p.I1198T	SIDM00016	Neuroblastoma	GDSC	ERKVLKELQ	DEG_APCC_DBOX_1	0.25
p.I1198T	EMC-BAC-1	lung	COSMIC	ERKVLKELQ	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02224	Centromere-associated protein E	DEG_APCC_DBOX_1	1201:1209	ERKVLKELQ	APC,CDC20,FZR1	0.834	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons