DegronMD

Uniprot ID: Q02224

Source protein: Centromere-associated protein E

Source gene: CENPE

Class: LIG_APCC_ABBA_1

Location: 132:137

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7553

ASA_SCORE: 26.9667

COIL: 0.3508

CONS_SCORE: 0.7994

DSS_SCORE: 0.0253

HELIX: 0.0887

FCONS_SCORE: 1.4396

RIG_SCORE: 0.9014

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q147E	TCGA-34-2600	LUSC	TCGA	MEIYNE	LIG_APCC_ABBA_1	0.0556
p.Q147E	DO27081	LUSC	ICGC	MEIYNE	LIG_APCC_ABBA_1	0.0556
p.V129L	TCGA-78-7148	LUAD	TCGA	MEIYNE	LIG_APCC_ABBA_1	0.25
p.V129L	DO26112	LUAD	ICGC	MEIYNE	LIG_APCC_ABBA_1	0.25
p.L126I	TCGA-B5-A11N	UCEC	TCGA	MEIYNE	LIG_APCC_ABBA_1	0.1667
p.L126I	DO41458	UCEC	ICGC	MEIYNE	LIG_APCC_ABBA_1	0.1667
p.E137K	TCGA-BH-A0B6	BRCA	TCGA	MEIYNE	LIG_APCC_ABBA_1	0.7022
p.E137K	DO2641	BRCA	ICGC	MEIYNE	LIG_APCC_ABBA_1	0.7022
p.R128C	TCGA-BR-8680	STAD	TCGA	MEIYNE	LIG_APCC_ABBA_1	0.2222
p.R128C	DO47769	STAD	ICGC	MEIYNE	LIG_APCC_ABBA_1	0.2222
p.D122A	TCGA-R5-A7ZI	STAD	TCGA	MEIYNE	LIG_APCC_ABBA_1	0.0556
p.D122A	DO222342	STAD	ICGC	MEIYNE	LIG_APCC_ABBA_1	0.0556
p.D122H	TCGA-S5-A6DX	BLCA	TCGA	MEIYNE	LIG_APCC_ABBA_1	0.0556
p.D122H	DO51903	BLCA	ICGC	MEIYNE	LIG_APCC_ABBA_1	0.0556
p.R128H	DO51169	PAEN	ICGC	MEIYNE	LIG_APCC_ABBA_1	0.2222
p.D141Y	SIDM01611	Endometrial Carcinoma	GDSC	MEIYNE	LIG_APCC_ABBA_1	0.2222
p.D141Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	MEIYNE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02224	Centromere-associated protein E	LIG_APCC_ABBA_1	132:137	MEIYNE	APC,CDC20,FZR1	0.7553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons