DegronMD

Uniprot ID: Q02224

Source protein: Centromere-associated protein E

Source gene: CENPE

Class: DEG_APCC_KENBOX_2

Location: 1073:1077

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6832

ASA_SCORE: 103.1

COIL: 0.053

CONS_SCORE: 0.3226

DSS_SCORE: 0.3883

HELIX: 0.9476

FCONS_SCORE: 1.1394

RIG_SCORE: 0.7857

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1063M	TCGA-50-5066	LUAD	TCGA	LKENI	DEG_APCC_KENBOX_2	0.0556
p.I1063M	DO25040	LUAD	ICGC	LKENI	DEG_APCC_KENBOX_2	0.0556
p.E1078K	DO48408	BLCA	ICGC	LKENI	DEG_APCC_KENBOX_2	0.3056
p.T1080A	SIDM00771	Non-Small Cell Lung Carcinoma	GDSC	LKENI	DEG_APCC_KENBOX_2	0.25
p.T1080A	NCI-H1792	lung	COSMIC	LKENI	DEG_APCC_KENBOX_2	0.25
p.I1077V	SIDM00217	Colorectal Carcinoma	GDSC	LKENI	DEG_APCC_KENBOX_2	0.5965
p.I1077V	SNU-1040	large_intestine	COSMIC	LKENI	DEG_APCC_KENBOX_2	0.5965
p.K1085N	ACH-002800	Unknown	CCLE	LKENI	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02224	Centromere-associated protein E	DEG_APCC_KENBOX_2	1073:1077	LKENI	APC,CDC20,FZR1	0.6832	More...
Q8NG31	Kinetochore scaffold 1	DEG_APCC_KENBOX_2	1533:1537	LKENI	APC,CDC20,FZR1	0.9726	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons