DegronMD

Uniprot ID: Q02224

Source protein: Centromere-associated protein E

Source gene: CENPE

Class: DEG_APCC_DBOX_1

Location: 966:974

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9386

ASA_SCORE: 95.1889

COIL: 0.0703

CONS_SCORE: 0.2697

DSS_SCORE: 0.4768

HELIX: 0.9308

FCONS_SCORE: 1.0883

RIG_SCORE: 0.7543

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A969V	TCGA-B5-A0JY	UCEC	TCGA	LRNALESLK	DEG_APCC_DBOX_1	0.5825
p.A969V	DO43041	UCEC	ICGC	LRNALESLK	DEG_APCC_DBOX_1	0.5825
p.K984I	TCGA-BC-A10Z	LIHC	TCGA	LRNALESLK	DEG_APCC_DBOX_1	0.1667
p.K984I	DO23043	LIHC	ICGC	LRNALESLK	DEG_APCC_DBOX_1	0.1667
p.H976L	TCGA-CN-6021	HNSC	TCGA	LRNALESLK	DEG_APCC_DBOX_1	0.2778
p.H976L	DO15847	HNSC	ICGC	LRNALESLK	DEG_APCC_DBOX_1	0.2778
p.R967Q	TCGA-D1-A17B	UCEC	TCGA	LRNALESLK	DEG_APCC_DBOX_1	0.7329
p.R967Q	TCGA-D8-A1JK	BRCA	TCGA	LRNALESLK	DEG_APCC_DBOX_1	0.7329
p.R967Q	DO3880	BRCA	ICGC	LRNALESLK	DEG_APCC_DBOX_1	0.7329
p.R967Q	DO231742	LINC	ICGC	LRNALESLK	DEG_APCC_DBOX_1	0.7329
p.R967Q	DO43017	UCEC	ICGC	LRNALESLK	DEG_APCC_DBOX_1	0.7329
p.R967Q	SIDM00419	Ewing's Sarcoma	GDSC	LRNALESLK	DEG_APCC_DBOX_1	0.7329
p.N968T	DO5745	BRCA	ICGC	LRNALESLK	DEG_APCC_DBOX_1	0.5944
p.L970R	DO234274	ESAD	ICGC	LRNALESLK	DEG_APCC_DBOX_1	0.8428
p.L970I	DO234274	ESAD	ICGC	LRNALESLK	DEG_APCC_DBOX_1	0.7174
p.I960V	DO232761	PBCA	ICGC	LRNALESLK	DEG_APCC_DBOX_1	0.1667
p.N957H	SIDM00227	Neuroblastoma	GDSC	LRNALESLK	DEG_APCC_DBOX_1	0.0833
p.N957H	GI-ME-N	autonomic_ganglia	COSMIC	LRNALESLK	DEG_APCC_DBOX_1	0.0833
p.R967L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LRNALESLK	DEG_APCC_DBOX_1	0.8428
p.R967L	ACH-000951	Lung Cancer	CCLE	LRNALESLK	DEG_APCC_DBOX_1	0.8428
p.R967L	NCI-H2342	lung	COSMIC	LRNALESLK	DEG_APCC_DBOX_1	0.8428
p.N957S	SIDM00217	Colorectal Carcinoma	GDSC	LRNALESLK	DEG_APCC_DBOX_1	0.0833
p.N957S	SNU-1040	large_intestine	COSMIC	LRNALESLK	DEG_APCC_DBOX_1	0.0833
p.E964Q	ACH-000530	Lung Cancer	CCLE	LRNALESLK	DEG_APCC_DBOX_1	0.2778
p.E964Q	DMS-114	lung	COSMIC	LRNALESLK	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02224	Centromere-associated protein E	DEG_APCC_DBOX_1	966:974	LRNALESLK	APC,CDC20,FZR1	0.9386	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRNALESLK

Degron related mutations and impact score

Drug responses associated with CENPE mutations

All proteins holding degron of LRNALESLK