DegronMD

Uniprot ID: Q02224

Source protein: Centromere-associated protein E

Source gene: CENPE

Class: DEG_APCC_DBOX_1

Location: 1372:1380

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5479

ASA_SCORE: 97.5889

COIL: 0.0188

CONS_SCORE: 0.2157

DSS_SCORE: 0.5075

HELIX: 0.9812

FCONS_SCORE: 1.0388

RIG_SCORE: 0.7709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1363F	TCGA-14-0817	GBM	TCGA	IRETLAKIQ	DEG_APCC_DBOX_1	0.0833
p.V1363F	DO13653	GBM	ICGC	IRETLAKIQ	DEG_APCC_DBOX_1	0.0833
p.S1384G	TCGA-44-3918	LUAD	TCGA	IRETLAKIQ	DEG_APCC_DBOX_1	0.2222
p.S1384G	DO23732	LUAD	ICGC	IRETLAKIQ	DEG_APCC_DBOX_1	0.2222
p.E1374K	TCGA-CN-4735	HNSC	TCGA	IRETLAKIQ	DEG_APCC_DBOX_1	0.591
p.E1374K	DO14172	HNSC	ICGC	IRETLAKIQ	DEG_APCC_DBOX_1	0.591
p.L1368M	DO229057	LICA	ICGC	IRETLAKIQ	DEG_APCC_DBOX_1	0.2222
p.H1365L	SIDM00650	Small Cell Lung Carcinoma	GDSC	IRETLAKIQ	DEG_APCC_DBOX_1	0.1389
p.H1365L	SIDM00875	Breast Carcinoma	GDSC	IRETLAKIQ	DEG_APCC_DBOX_1	0.1389
p.H1365L	SIDM00068	Colorectal Carcinoma	GDSC	IRETLAKIQ	DEG_APCC_DBOX_1	0.1389
p.H1365L	SIDM01681	Non-Cancerous	GDSC	IRETLAKIQ	DEG_APCC_DBOX_1	0.1389
p.H1365L	SIDM01525	Acute Myeloid Leukemia	GDSC	IRETLAKIQ	DEG_APCC_DBOX_1	0.1389
p.A1390S	ACH-000803	Lung Cancer	CCLE	IRETLAKIQ	DEG_APCC_DBOX_1	0.0556
p.A1390S	COLO-668	lung	COSMIC	IRETLAKIQ	DEG_APCC_DBOX_1	0.0556
p.V1378M	ACH-000960	Leukemia	CCLE	IRETLAKIQ	DEG_APCC_DBOX_1	0.7208
p.V1378M	REH	haematopoietic_and_lymphoid_tissue	COSMIC	IRETLAKIQ	DEG_APCC_DBOX_1	0.7208
p.N1372D	ACH-000997	Colon/Colorectal Cancer	CCLE	IRETLAKIQ	DEG_APCC_DBOX_1	0.6932
p.N1372D	HCT-15	large_intestine	COSMIC	IRETLAKIQ	DEG_APCC_DBOX_1	0.6932
p.S1379N	8-MG-BA	central_nervous_system	COSMIC	IRETLAKIQ	DEG_APCC_DBOX_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02224	Centromere-associated protein E	DEG_APCC_DBOX_1	1372:1380	IRETLAKIQ	APC,CDC20,FZR1	0.5479	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons